Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens

Induction of phase 2 detoxication enzymes [e.g., glutathione transferases, epoxide hydrolase, NAD(P)H: quinone reductase, and glucuronosyltransferases] is a powerful strategy for achieving protection against carcinogenesis, mutagenesis, and other forms of toxicity of electrophiles and reactive forms...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1997-09, Vol.94 (19), p.10367-10372
Hauptverfasser:	Fahey, J.W, Zhang, Y.S, Talalay, P
Format:	Artikel
Sprache:	eng
Schlagworte:	9,10-Dimethyl-1,2-benzanthracene ACTIVADOR ENZIMATICO ACTIVATEUR D'ENZYME ACTIVIDAD ENZIMATICA ACTIVITE ENZYMATIQUE ADMINISTRACION ORAL ADMINISTRATION ORALE Animals Anticarcinogenic Agents - isolation & purification Anticarcinogenic Agents - pharmacology Biological Sciences Brassica - chemistry Brassica - growth & development BRASSICA OLERACEA ITALICA BRASSICACEAE BROCCOLI BROCOLI Cancer CARCINOGENOS CARCINOGENS CRUCIFERAE CRUCIFEROUS VEGETABLES DIMETHYLBENZ(A)ANTHRACENE ENFERMEDADES GLANDULAS MAMARIAS ENZYME ACTIVATORS Enzyme Induction Enzymes ENZYMIC ACTIVITY EXTRACTOS VEGETALES EXTRAIT D'ORIGINE VEGETALE Female Germination GLUCORAPHANIN GLUCOSINOLATE GLUCOSINOLATES Glucosinolates - isolation & purification Glucosinolates - pharmacology GLUCOSINOLATOS HIDROLASAS HORTALIZAS DE HOJA HYDROLASE HYDROLASES Indoles ISOTHIOCYANATES Isothiocyanates - isolation & purification Isothiocyanates - pharmacology LEAF VEGETABLES LEGUME FEUILLE MALADIE DES GLANDES MAMMAIRES MAMMARY GLAND DISEASES Mammary Neoplasms, Experimental - chemically induced Mammary Neoplasms, Experimental - prevention & control Medical research MYROSINASE NEOPLASMAS NEOPLASME NEOPLASMS ORAL ADMINISTRATION OXIDOREDUCTASES OXIDORREDUCTASAS OXYDOREDUCTASE PLANT EXTRACTS Plants PREVENTION QUINONE REDUCTASE RAT RATA RATS Rats, Sprague-Dawley Solvents Sprouts SUBSTANCE CANCERIGENE SULFORAPHANE THIOCYANATE THIOCYANATES THIOGLUCOSIDASE TIOCIANATOS Tumors Vegetables
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