The polymorphisms S503P and Q576R in the interleukin‐4 receptor α gene are associated with atopy and influence the signal transduction

Interleukin‐4 (IL‐4) plays a major role in immunoglobulin E (IgE) production. Its signal is conferred to effector cells through binding to the α chain of the IL‐4 receptor (IL‐4Rα). We present further evidence for polymorphisms in the IL‐4Rα gene having an effect on IgE regulation. For two of four c...

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Veröffentlicht in:	Immunology 1999-03, Vol.96 (3), p.365-371
Hauptverfasser:	Kruse, S, Japha, T, Tedner, M, Sparholt, S H, Forster, J, Kuehr, J, Deichmann, K A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Alleles Cell Culture Techniques Child Humans Hypersensitivity, Immediate - genetics Hypersensitivity, Immediate - immunology Immunoglobulin E - blood Linkage Disequilibrium Original Phosphorylation Polymerase Chain Reaction Polymorphism, Genetic Receptors, Interleukin-4 - genetics Signal Transduction - genetics Signal Transduction - immunology
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