The safety and longevity of DNA vaccines for fish

A plasmid that contained the cytomegalovirus (CMV)‐promoter‐driven lacZ reporter gene (pCMV‐lacZ) remained in the epaxial muscle of five of eight goldfish as covalently closed circles, the most functional form of plasmid, for at least 70 days at 22°. It was not present in the gills or elsewhere by p...

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Veröffentlicht in:	Immunology 1999-02, Vol.96 (2), p.307-313
Hauptverfasser:	Kanellos, T, Sylvester, I D, Ambali, A G, Howard, C R, Russell, P H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibody Formation beta-Galactosidase - analysis Brackish Escherichia coli Freshwater Goldfish - immunology Human cytomegalovirus Immunity, Cellular Kidney - immunology Marine Muscle, Skeletal - enzymology Original Pisces Plasmids Polymerase Chain Reaction Time Factors Vaccines, DNA - administration & dosage
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