Islet transplantation in patients with autoimmune diabetes induces homeostatic cytokines that expand autoreactive memory T cells

Successful transplantation requires the prevention of allograft rejection and, in the case of transplantation to treat autoimmune disease, the suppression of autoimmune responses. The standard immunosuppressive treatment regimen given to patients with autoimmune type 1 diabetes who have received an...

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Veröffentlicht in:	The Journal of clinical investigation 2008-05, Vol.118 (5), p.1806-1814
Hauptverfasser:	Monti, Paolo, Scirpoli, Miriam, Maffi, Paola, Ghidoli, Nadia, De Taddeo, Francesca, Bertuzzi, Federico, Piemonti, Lorenzo, Falcone, Marika, Secchi, Antonio, Bonifacio, Ezio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Autoimmune diseases Biomedical research Care and treatment Cell growth Cytokines Diabetes Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - immunology Diabetes Mellitus, Type 1 - therapy Health aspects Homeostasis Humans Immune system Immunosuppressive Agents - pharmacology Immunosuppressive Agents - therapeutic use Interleukin-15 - blood Interleukin-15 - immunology Interleukin-7 - blood Interleukin-7 - immunology Islands Islets of Langerhans Transplantation Lymphocytes Male Mice Mycophenolic Acid - analogs & derivatives Mycophenolic Acid - pharmacology Mycophenolic Acid - therapeutic use Physiological aspects Sirolimus - pharmacology Sirolimus - therapeutic use T cell receptors T-Lymphocyte Subsets - immunology T-Lymphocytes - drug effects T-Lymphocytes - immunology Tacrolimus - pharmacology Tacrolimus - therapeutic use Transplantation of organs, tissues, etc Transplants & implants
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