Diminished Ret expression compromises neuronal survival in the colon and causes intestinal aganglionosis in mice

Mutations in the RET gene are the primary cause of Hirschsprung disease (HSCR), or congenital intestinal aganglionosis. However, how RET malfunction leads to HSCR is not known. It has recently been shown that glial cell line-derived neurotrophic factor (GDNF) family receptor alpha1 (GFRalpha1), whic...

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Veröffentlicht in:	The Journal of clinical investigation 2008-05, Vol.118 (5), p.1890-1898
Hauptverfasser:	Uesaka, Toshihiro, Nagashimada, Mayumi, Yonemura, Shigenobu, Enomoto, Hideki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - physiology Biomedical research Care and treatment Cell death Cell Movement - physiology Cell Survival Colon Colon - cytology Colon - metabolism Colon - pathology Congenital diseases Development and progression Diagnosis Disease Models, Animal Enteric Nervous System - cytology Etiology Female Fetuses Gene expression Gene mutations Genotype & phenotype Glial Cell Line-Derived Neurotrophic Factor Receptors - genetics Glial Cell Line-Derived Neurotrophic Factor Receptors - metabolism Health aspects Hirschsprung Disease - genetics Hirschsprung Disease - pathology Hirschsprung's disease Humans Kinases Male Methods Mice Mice, Knockout Mutation Nervous system Neurons Neurons - cytology Neurons - physiology Proto-Oncogene Proteins c-ret - genetics Proto-Oncogene Proteins c-ret - metabolism Risk factors
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