Relation of Depression, Natural Killer Cell Function, and Infections after Coronary Artery Bypass in Women
Background: After hospital discharge for coronary artery bypass grafting (CABG), infection is a common cause of morbidity. Although depression has been associated with immune dysfunction, its role in post-CABG infection is unknown. Aims: The purpose of this study was to: 1) compare natural killer ce...
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| Veröffentlicht in: | European journal of cardiovascular nursing : journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology 2008-03, Vol.7 (1), p.52-58 |
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| container_title | European journal of cardiovascular nursing : journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology |
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| creator | Doering, Lynn V. Martínez-Maza, Otoniel Vredevoe, Donna L. Cowan, Marie J. |
| description | Background: After hospital discharge for coronary artery bypass grafting (CABG), infection is a common cause of morbidity. Although depression has been associated with immune dysfunction, its role in post-CABG infection is unknown.
Aims: The purpose of this study was to: 1) compare natural killer cell cytotoxicity (NKCC) and post-hospitalization infections in depressed and non-depressed women after CABG; and 2) test whether NKCC mediated the relationship between post-discharge depression and infections.
Methods: Sixty-seven women recovering from CABG were assessed for depression prior to hospital discharge and followed for six months. Major depression was identified by a structured clinical interview. Infections were identified by patient report using the Modified Health Review and by medical chart audit.
Results: Compared to non-depressed women after CABG, women with major depression had reduced NKCC, more all-cause infections, and more self-reported illnesses. Although NKCC did not mediate the relationship between depression and wound (i.e. incisional) infections after CABG, it did mediate the relationship between depression and non-wound infections, including pneumonias and upper respiratory infections.
Conclusions: For the first six months after CABG, women with major depression are at increased risk for infections. Natural killer cell cytotoxicity may be related to this phenomenon, particularly to non-wound infections. |
| doi_str_mv | 10.1016/j.ejcnurse.2007.07.004 |
| format | Article |
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Aims: The purpose of this study was to: 1) compare natural killer cell cytotoxicity (NKCC) and post-hospitalization infections in depressed and non-depressed women after CABG; and 2) test whether NKCC mediated the relationship between post-discharge depression and infections.
Methods: Sixty-seven women recovering from CABG were assessed for depression prior to hospital discharge and followed for six months. Major depression was identified by a structured clinical interview. Infections were identified by patient report using the Modified Health Review and by medical chart audit.
Results: Compared to non-depressed women after CABG, women with major depression had reduced NKCC, more all-cause infections, and more self-reported illnesses. Although NKCC did not mediate the relationship between depression and wound (i.e. incisional) infections after CABG, it did mediate the relationship between depression and non-wound infections, including pneumonias and upper respiratory infections.
Conclusions: For the first six months after CABG, women with major depression are at increased risk for infections. Natural killer cell cytotoxicity may be related to this phenomenon, particularly to non-wound infections.</description><identifier>ISSN: 1474-5151</identifier><identifier>EISSN: 1873-1953</identifier><identifier>DOI: 10.1016/j.ejcnurse.2007.07.004</identifier><identifier>PMID: 17716947</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Case-Control Studies ; Coronary Artery Bypass - adverse effects ; Coronary Artery Bypass - psychology ; Depression - blood ; Depression - diagnosis ; Depression - epidemiology ; Depression - etiology ; Female ; Flow Cytometry ; Humans ; Infections - blood ; Infections - epidemiology ; Infections - etiology ; Killer Cells, Natural - immunology ; Linear Models ; Longitudinal Studies ; Mental Status Schedule ; Middle Aged ; Multivariate Analysis ; Outcome Assessment, Health Care ; Prevalence ; Psychiatric Status Rating Scales ; Severity of Illness Index ; Women's Health</subject><ispartof>European journal of cardiovascular nursing : journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology, 2008-03, Vol.7 (1), p.52-58</ispartof><rights>2008 European Society of Cardiology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c488t-a109b86f5924aad83bae99a58749156579ae5db4a28a8f993d0b53ffccd2073c3</citedby><cites>FETCH-LOGICAL-c488t-a109b86f5924aad83bae99a58749156579ae5db4a28a8f993d0b53ffccd2073c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1016/j.ejcnurse.2007.07.004$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1016/j.ejcnurse.2007.07.004$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>230,314,780,784,885,21819,27924,27925,43621,43622</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17716947$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Doering, Lynn V.</creatorcontrib><creatorcontrib>Martínez-Maza, Otoniel</creatorcontrib><creatorcontrib>Vredevoe, Donna L.</creatorcontrib><creatorcontrib>Cowan, Marie J.</creatorcontrib><title>Relation of Depression, Natural Killer Cell Function, and Infections after Coronary Artery Bypass in Women</title><title>European journal of cardiovascular nursing : journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology</title><addtitle>Eur J Cardiovasc Nurs</addtitle><description>Background: After hospital discharge for coronary artery bypass grafting (CABG), infection is a common cause of morbidity. Although depression has been associated with immune dysfunction, its role in post-CABG infection is unknown.
Aims: The purpose of this study was to: 1) compare natural killer cell cytotoxicity (NKCC) and post-hospitalization infections in depressed and non-depressed women after CABG; and 2) test whether NKCC mediated the relationship between post-discharge depression and infections.
Methods: Sixty-seven women recovering from CABG were assessed for depression prior to hospital discharge and followed for six months. Major depression was identified by a structured clinical interview. Infections were identified by patient report using the Modified Health Review and by medical chart audit.
Results: Compared to non-depressed women after CABG, women with major depression had reduced NKCC, more all-cause infections, and more self-reported illnesses. Although NKCC did not mediate the relationship between depression and wound (i.e. incisional) infections after CABG, it did mediate the relationship between depression and non-wound infections, including pneumonias and upper respiratory infections.
Conclusions: For the first six months after CABG, women with major depression are at increased risk for infections. Natural killer cell cytotoxicity may be related to this phenomenon, particularly to non-wound infections.</description><subject>Case-Control Studies</subject><subject>Coronary Artery Bypass - adverse effects</subject><subject>Coronary Artery Bypass - psychology</subject><subject>Depression - blood</subject><subject>Depression - diagnosis</subject><subject>Depression - epidemiology</subject><subject>Depression - etiology</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Humans</subject><subject>Infections - blood</subject><subject>Infections - epidemiology</subject><subject>Infections - etiology</subject><subject>Killer Cells, Natural - immunology</subject><subject>Linear Models</subject><subject>Longitudinal Studies</subject><subject>Mental Status Schedule</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Outcome Assessment, Health Care</subject><subject>Prevalence</subject><subject>Psychiatric Status Rating Scales</subject><subject>Severity of Illness Index</subject><subject>Women's Health</subject><issn>1474-5151</issn><issn>1873-1953</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUU1v1DAQtRCIloW_UPkEF7LYsR3bF6SytFBRgYRAHK2JY5dEWXtrJ0j77-t0l68LSGPZT_PmeWYeQmeUrCmhzath7QYb5pTduiZErpcg_AE6pUqyimrBHpY3l7wSVNAT9CTngRAqy3mMTqiUtNFcnqLhsxth6mPA0eO3bpdczgW9xB9hmhOM-EM_ji7hjRtHfDkHO91nIXT4Knh3DzMGPy2cmGKAtMfnqcA9frPfQc64D_hb3LrwFD3yMGb37Hiv0NfLiy-b99X1p3dXm_PrynKlpgoo0a1qvNA1B-gUa8FpDUJJrqlohNTgRNdyqBUorzXrSCuY99Z2NZHMshV6fdDdze3WddaFqQxidqnfluZMhN78nQn9d3MTf5i61nXDaRF4cRRI8XZ2eTLbPtuyAAguztnIhjNBdPl6hZ7_m0lqzalaJJsD0aaYc3L-VzuUmMVQM5ifhprFULME4aXw7M9hfpcdHSwEdiBkuHFmiHMKZbn_k70Dtm6yJg</recordid><startdate>20080301</startdate><enddate>20080301</enddate><creator>Doering, Lynn V.</creator><creator>Martínez-Maza, Otoniel</creator><creator>Vredevoe, Donna L.</creator><creator>Cowan, Marie J.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>ASE</scope><scope>FPQ</scope><scope>K6X</scope><scope>5PM</scope></search><sort><creationdate>20080301</creationdate><title>Relation of Depression, Natural Killer Cell Function, and Infections after Coronary Artery Bypass in Women</title><author>Doering, Lynn V. ; Martínez-Maza, Otoniel ; Vredevoe, Donna L. ; Cowan, Marie J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c488t-a109b86f5924aad83bae99a58749156579ae5db4a28a8f993d0b53ffccd2073c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Case-Control Studies</topic><topic>Coronary Artery Bypass - adverse effects</topic><topic>Coronary Artery Bypass - psychology</topic><topic>Depression - blood</topic><topic>Depression - diagnosis</topic><topic>Depression - epidemiology</topic><topic>Depression - etiology</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>Humans</topic><topic>Infections - blood</topic><topic>Infections - epidemiology</topic><topic>Infections - etiology</topic><topic>Killer Cells, Natural - immunology</topic><topic>Linear Models</topic><topic>Longitudinal Studies</topic><topic>Mental Status Schedule</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Outcome Assessment, Health Care</topic><topic>Prevalence</topic><topic>Psychiatric Status Rating Scales</topic><topic>Severity of Illness Index</topic><topic>Women's Health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Doering, Lynn V.</creatorcontrib><creatorcontrib>Martínez-Maza, Otoniel</creatorcontrib><creatorcontrib>Vredevoe, Donna L.</creatorcontrib><creatorcontrib>Cowan, Marie J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>British Nursing Index</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>British Nursing Index</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European journal of cardiovascular nursing : journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Doering, Lynn V.</au><au>Martínez-Maza, Otoniel</au><au>Vredevoe, Donna L.</au><au>Cowan, Marie J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relation of Depression, Natural Killer Cell Function, and Infections after Coronary Artery Bypass in Women</atitle><jtitle>European journal of cardiovascular nursing : journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology</jtitle><addtitle>Eur J Cardiovasc Nurs</addtitle><date>2008-03-01</date><risdate>2008</risdate><volume>7</volume><issue>1</issue><spage>52</spage><epage>58</epage><pages>52-58</pages><issn>1474-5151</issn><eissn>1873-1953</eissn><abstract>Background: After hospital discharge for coronary artery bypass grafting (CABG), infection is a common cause of morbidity. Although depression has been associated with immune dysfunction, its role in post-CABG infection is unknown.
Aims: The purpose of this study was to: 1) compare natural killer cell cytotoxicity (NKCC) and post-hospitalization infections in depressed and non-depressed women after CABG; and 2) test whether NKCC mediated the relationship between post-discharge depression and infections.
Methods: Sixty-seven women recovering from CABG were assessed for depression prior to hospital discharge and followed for six months. Major depression was identified by a structured clinical interview. Infections were identified by patient report using the Modified Health Review and by medical chart audit.
Results: Compared to non-depressed women after CABG, women with major depression had reduced NKCC, more all-cause infections, and more self-reported illnesses. Although NKCC did not mediate the relationship between depression and wound (i.e. incisional) infections after CABG, it did mediate the relationship between depression and non-wound infections, including pneumonias and upper respiratory infections.
Conclusions: For the first six months after CABG, women with major depression are at increased risk for infections. Natural killer cell cytotoxicity may be related to this phenomenon, particularly to non-wound infections.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>17716947</pmid><doi>10.1016/j.ejcnurse.2007.07.004</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | Access via SAGE; MEDLINE; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Case-Control Studies Coronary Artery Bypass - adverse effects Coronary Artery Bypass - psychology Depression - blood Depression - diagnosis Depression - epidemiology Depression - etiology Female Flow Cytometry Humans Infections - blood Infections - epidemiology Infections - etiology Killer Cells, Natural - immunology Linear Models Longitudinal Studies Mental Status Schedule Middle Aged Multivariate Analysis Outcome Assessment, Health Care Prevalence Psychiatric Status Rating Scales Severity of Illness Index Women's Health |
| title | Relation of Depression, Natural Killer Cell Function, and Infections after Coronary Artery Bypass in Women |
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