The Vps27/Hse1 Complex Is a GAT Domain-Based Scaffold for Ubiquitin-Dependent Sorting

The yeast Vps27/Hse1 complex and the homologous mammalian Hrs/STAM complex deliver ubiquitinated transmembrane proteins to the ESCRT endosomal-sorting pathway. The Vps27/Hse1 complex directly binds to ubiquitinated transmembrane proteins and recruits both ubiquitin ligases and deubiquitinating enzym...

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Veröffentlicht in:	Developmental cell 2007-06, Vol.12 (6), p.973-986
Hauptverfasser:	Prag, Gali, Watson, Hadiya, Kim, Young C., Beach, Bridgette M., Ghirlando, Rodolfo, Hummer, Gerhard, Bonifacino, Juan S., Hurley, James H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Biological and medical sciences Cell differentiation, maturation, development, hematopoiesis Cell physiology CELLBIO Chromatography, Gel Crystallography, X-Ray Endosomal Sorting Complexes Required for Transport Fundamental and applied biological sciences. Psychology Immunoprecipitation Models, Molecular Molecular and cellular biology Molecular Sequence Data Mutagenesis, Site-Directed Mutation - genetics Protein Binding Protein Structure, Tertiary Protein Transport PROTEINS Receptors, Cytoplasmic and Nuclear - chemistry Receptors, Cytoplasmic and Nuclear - genetics Receptors, Cytoplasmic and Nuclear - metabolism Saccharomyces cerevisiae - chemistry Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Sequence Homology, Amino Acid Ubiquitin - metabolism Vesicular Transport Proteins - chemistry Vesicular Transport Proteins - genetics Vesicular Transport Proteins - metabolism
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