Arthritis induced by posttranslationally modified (citrullinated) fibrinogen in DR4-IE transgenic mice

Rheumatoid arthritis (RA) is a common autoimmune disease that afflicts the synovium of diarthrodial joints. The pathogenic mechanisms inciting this disease are not fully characterized, but may involve the loss of tolerance to posttranslationally modified (citrullinated) antigens. We have demonstrate...

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Veröffentlicht in:	The Journal of experimental medicine 2008-04, Vol.205 (4), p.967-979
Hauptverfasser:	Hill, Jonathan A, Bell, David A, Brintnell, William, Yue, David, Wehrli, Bret, Jevnikar, Anthony M, Lee, David M, Hueber, Wolfgang, Robinson, William H, Cairns, Ewa
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antibody Formation - immunology Arthritis, Rheumatoid - chemically induced Arthritis, Rheumatoid - immunology Cell Proliferation Cytokines - biosynthesis Epitopes - immunology Female Fibrinogen - chemistry Fibrinogen - immunology HLA-DR4 Antigen - genetics HLA-DR4 Antigen - immunology Humans Immunization Immunoglobulin G - immunology Immunohistochemistry Inflammation Joints - pathology Male Mice Mice, Transgenic Molecular Sequence Data Protein Array Analysis Protein Processing, Post-Translational Synovial Membrane - chemistry T-Lymphocytes - drug effects T-Lymphocytes - immunology
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