CXCR4 is required for the quiescence of primitive hematopoietic cells

The quiescence of hematopoietic stem cells (HSCs) is critical for preserving a lifelong steady pool of HSCs to sustain the highly regenerative hematopoietic system. It is thought that specialized niches in which HSCs reside control the balance between HSC quiescence and self-renewal, yet little is k...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	The Journal of experimental medicine 2008-04, Vol.205 (4), p.777-783
Hauptverfasser:	Nie, Yuchun, Han, Yoon-Chi, Zou, Yong-Rui
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Marrow Cells - cytology Brief Definitive Reports Cell Cycle Cell Proliferation Chemokine CXCL12 - metabolism Hematopoiesis Hematopoietic Stem Cells - cytology Hematopoietic System - cytology Mice Multipotent Stem Cells - cytology Receptors, CXCR4 - deficiency Receptors, CXCR4 - metabolism Signal Transduction
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!