Differences between CD8+ T cells in lupus‐prone (NZB × NZW) F1 mice and healthy (BALB/c × NZW) F1 mice may influence autoimmunity in the lupus model

Immunization with portions of a murine antibody to DNA induced Ig peptide‐reactive peripheral CD8+ inhibitory T (Ti) cells in non‐autoimmune (BALB/c × NZW) F1 (CWF1) mice. Those Ti suppressed in vitro production of IgG anti‐DNA by lymphocytes from MHC‐matched, lupus‐prone (NZB × NZW) F1 (BWF1) mice,...

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Veröffentlicht in:	European journal of immunology 2004-09, Vol.34 (9), p.2489-2499
Hauptverfasser:	Karpouzas, George A., La Cava, Antonio, Ebling, Fanny M., Singh, Ram Raj, Hahn, Bevra H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Autoantibodies - biosynthesis Autoimmunity CD8-Positive T-Lymphocytes - immunology Disease Models, Animal Female Immunization Immunologic Memory Inhibitory CD8+ T cells Interleukin-2 - analysis Lupus Lupus Erythematosus, Systemic - immunology Lymphocyte Activation Mice Mice, Inbred C57BL Mice, Inbred NZB Transforming Growth Factor beta - analysis Transforming Growth Factor beta1
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