Hypoxia inhibits human recombinant large conductance, Ca2+-activated K+ (maxi-K) channels by a mechanism which is membrane delimited and Ca2+ sensitive

Large conductance, Ca 2+ -activated K + (maxi-K) channel activity was recorded in excised, inside-out patches from HEK 293 cells stably co-expressing the α- and β-subunits of human brain maxi-K channels. At +50 mV, and in the presence of 300 n m , single channel activity was acutely and reversibly...

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Veröffentlicht in:The Journal of physiology 2002-05, Vol.540 (3), p.771-780
Hauptverfasser: Lewis, A., Peers, C., Ashford, M. L. J., Kemp, P. J.
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Sprache:eng
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