Intracellular Cyclic AMP, Not Calcium, Determines the Direction of Vesicle Movement in Melanophores: Direct Measurement by Fluorescence Ratio Imaging

Intracellular movement of vesiculated pigment granules in angelfish melanophores is regulated by a signalling pathway that triggers kinesin and dynein-like microtubule motor proteins. We have tested the relative importance of intracellular Ca2+([ Ca2+]i) vs cAMP ([ cAMP]i) in the control of such mot...

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Veröffentlicht in:	The Journal of cell biology 1992-04, Vol.117 (1), p.57-72
Hauptverfasser:	Sammak, Paul J., Adams, Stephen R., Harootunian, Alec T., Schliwa, Manfred, Tsien, Roger Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic alpha-Antagonists - pharmacology Adrenergic beta-Antagonists - pharmacology Aggregation Animals Atropine Biological and medical sciences Calcium Calcium - pharmacology Calcium - physiology Carbachol - pharmacology Cell aggregates Cell Aggregation - drug effects Cells Cyclic AMP - analogs & derivatives Cyclic AMP - pharmacology Cyclic AMP - physiology Digitonin - pharmacology Egtazic Acid - analogs & derivatives Egtazic Acid - pharmacology Epinephrine - pharmacology Ethers, Cyclic - pharmacology Fishes Fluorescence Fluorescent Dyes Fundamental and applied biological sciences. Psychology Fura-2 - analogs & derivatives Ionomycin - pharmacology Kinetics Melanophores Melanophores - cytology Melanophores - drug effects Melanophores - physiology Melanosomes Microscopy, Fluorescence Microtubules Okadaic Acid Organelles - drug effects Organelles - physiology Organelles - ultrastructure Phosphoprotein Phosphatases - antagonists & inhibitors Pigments Protein Kinases - metabolism Vertebrates: skin, associated glands, phaneres, light organs, various exocrine glands (salt gland, uropygial gland...), adipose tissue, connective tissue
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