Protein Phosphatase Type 1 in Mammalian Cell Mitosis: Chromosomal Localization and Involvement in Mitotic Exit

We have examined the role of protein phosphatase type 1 (PP-1) in mammalian cell mitosis. Immunofluorescence using anti-PP-1 antibodies revealed that PP-1, which is mainly localized in the cytoplasm of G1 and S phase cells, accumulates in the nucleus during G2 phase and intensely colocalizes with in...

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Veröffentlicht in:	The Journal of cell biology 1992-03, Vol.116 (6), p.1421-1430
Hauptverfasser:	Fernandez, Anne, Brautigan, David L., Ned J. C. Lamb
Format:	Artikel
Sprache:	eng
Schlagworte:	Anaphase Animals Antibodies B lymphocytes Biological and medical sciences Cell cycle Cell cycle, cell proliferation Cell Line Cell nucleus Cell Nucleus - enzymology Cell physiology Cells Cellular immunity Chromosomes - enzymology Fundamental and applied biological sciences. Psychology Immunoblotting Interphase Metaphase Microinjections Mitosis Molecular and cellular biology Phosphatases Phosphoprotein Phosphatases - analysis Phosphoprotein Phosphatases - antagonists & inhibitors Phosphoprotein Phosphatases - immunology Phosphoprotein Phosphatases - metabolism Rats
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