Fc Receptor Endocytosis Is Controlled by a Cytoplasmic Domain Determinant That Actively Prevents Coated Pit Localization

Macrophages and B-lymphocytes express two major isoforms of Fc receptor (FcRII-B2 and FcRII-B1) that exhibit distinct capacities for endocytosis. This difference in function reflects the presence of an in-frame insertion of 47 amino acids in the cytoplasmic domain of the lymphocyte isoform (FcRII-B1...

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Veröffentlicht in:	The Journal of cell biology 1992-02, Vol.116 (4), p.875-888
Hauptverfasser:	Miettinen, Heini M., Matter, Karl, Hunziker, Walter, Rose, John K., Mellman, Ira
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins Amino Acid Sequence Amino acids Animals Antigen-Antibody Complex B lymphocytes Base Sequence Biological and medical sciences Cell Line Cell lines Cell physiology CHO Cells Coated Pits, Cell-Membrane - metabolism COS cells Cricetinae Cytoplasm - metabolism Cytoskeleton - metabolism Endocytosis Fc receptors Fundamental and applied biological sciences. Psychology Immunohistochemistry Internalization Ligands lymphocytes B macrophages Microscopy, Immunoelectron Molecular and cellular biology Molecular Sequence Data Mutation Receptors Receptors, Fc - chemistry Receptors, Fc - genetics Receptors, Fc - metabolism Transfection Tyrosine - chemistry
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