Ras Isoprenylation Is Required for Ras-Induced but Not for NGF-Induced Neuronal Differentiation of PC12 Cells

We have used compactin, an inhibitor of mevalonate biosynthesis, to block p21ras posttranslational modification and membrane association in PC12 cells. Previous studies have demonstrated a requirement for isoprenylation for mitogenic effects of activated p21ras in mammalian cells and for function of...

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Veröffentlicht in:	The Journal of cell biology 1991-11, Vol.115 (3), p.795-808
Hauptverfasser:	Qiu, Meng-Sheng, Pitts, Andrew F., Winters, Timothy R., Green, Steven H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Differentiation - drug effects Cell differentiation, maturation, development, hematopoiesis Cell growth Cell lines Cell membranes Cell physiology Cells Cytosol - physiology Dexamethasone - pharmacology DNA Probes Epidermal Growth Factor - pharmacology Fundamental and applied biological sciences. Psychology Gene Expression - drug effects Genes, ras Hydroxymethylglutaryl-CoA Reductase Inhibitors Lovastatin - analogs & derivatives Lovastatin - pharmacology Molecular and cellular biology Nerve Growth Factors - pharmacology Nerves Neurites Neurons Neurons - cytology Neurons - drug effects Ornithine Decarboxylase - genetics PC12 Cells Phosphoproteins - biosynthesis Phosphoproteins - isolation & purification Polyisoprenyl Phosphates - metabolism Protein Processing, Post-Translational - drug effects Proteins Proto-Oncogene Proteins p21(ras) - genetics RNA, Neoplasm - genetics RNA, Neoplasm - isolation & purification Signal transduction Signal Transduction - drug effects
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