Lentivector-mediated rescue from cerebellar ataxia in a mouse model of spinocerebellar ataxia

Polyglutamine disorders are inherited neurodegenerative diseases caused by the accumulation of expanded polyglutamine protein (polyQ). Previously, we identified a new guanosine triphosphatase, CRAG, which facilitates the degradation of polyQ aggregates through the ubiquitin–proteasome pathway in cul...

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Veröffentlicht in:	EMBO reports 2008-04, Vol.9 (4), p.393-399
Hauptverfasser:	Torashima, Takashi, Koyama, Chiho, Iizuka, Akira, Mitsumura, Kazuhiro, Takayama, Kiyohiko, Yanagi, Shigeru, Oue, Miho, Yamaguchi, Haruyasu, Hirai, Hirokazu
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggregates Animals Brain Cell culture Cellular biology CRAG Dendrites - metabolism EMBO24 EMBO27 gene therapy Genetic Therapy - methods Genetic Vectors - genetics GTP Phosphohydrolases - metabolism GTP Phosphohydrolases - therapeutic use Immunohistochemistry Lentivirus Mice Mice, Transgenic Microscopy, Fluorescence Molecular biology Neurological disorders Peptides - metabolism polyglutamine disease Proteins Purkinje cell Purkinje Cells - metabolism Purkinje Cells - pathology Reverse Transcriptase Polymerase Chain Reaction Rodents Scientific Report Scientific Reports Spinocerebellar Ataxias - genetics Spinocerebellar Ataxias - metabolism Spinocerebellar Ataxias - therapy
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