Nitrous oxide-antinociception is mediated by opioid receptors and nitric oxide in the periaqueductal gray region of the midbrain

Abstract Previous studies have shown that nitrous oxide (N2 O)-induced antinociception is sensitive to antagonism by blockade of opioid receptors and also by inhibition of nitric oxide (NO) production. The present study was conducted to determine whether these occur within the same brain site. Mice...

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Veröffentlicht in:	European neuropsychopharmacology 2008-03, Vol.18 (3), p.194-199
Hauptverfasser:	Emmanouil, Dimitris E, Dickens, Andrea S, Heckert, Rick W, Ohgami, Yusuke, Chung, Eunhee, Han, Shujie, Quock, Raymond M
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics, Non-Narcotic - pharmacology Animals Antinociception Dose-Response Relationship, Drug Internal Medicine Male Mesencephalon - drug effects Mesencephalon - metabolism Mice Microinjections Naltrexone - analogs & derivatives Naltrexone - pharmacology Nitric oxide Nitric Oxide - physiology Nitrous oxide Nitrous Oxide - pharmacology Opioid receptors Pain Measurement - drug effects Periaqueductal gray Periaqueductal Gray - drug effects Periaqueductal Gray - metabolism Psychiatry Receptors, Opioid - drug effects
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