Nitrous oxide-antinociception is mediated by opioid receptors and nitric oxide in the periaqueductal gray region of the midbrain
Abstract Previous studies have shown that nitrous oxide (N2 O)-induced antinociception is sensitive to antagonism by blockade of opioid receptors and also by inhibition of nitric oxide (NO) production. The present study was conducted to determine whether these occur within the same brain site. Mice...
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| Veröffentlicht in: | European neuropsychopharmacology 2008-03, Vol.18 (3), p.194-199 |
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| creator | Emmanouil, Dimitris E Dickens, Andrea S Heckert, Rick W Ohgami, Yusuke Chung, Eunhee Han, Shujie Quock, Raymond M |
| description | Abstract Previous studies have shown that nitrous oxide (N2 O)-induced antinociception is sensitive to antagonism by blockade of opioid receptors and also by inhibition of nitric oxide (NO) production. The present study was conducted to determine whether these occur within the same brain site. Mice were stereotaxically implanted with microinjection cannulae in the periaqueductal gray (PAG) area of the midbrain. In saline-pretreated mice, exposure to 70% N2 O resulted in a concentration-dependent antinociceptive effect in the mouse abdominal constriction test. Pretreatment with an opioid antagonist in the PAG significantly antagonized the antinociceptive effect. Pretreatment with an inhibitor of NO production in the PAG also significantly antagonized the antinociceptive effect. These findings suggest that N2 O acts in the PAG via an NO-dependent, opioid receptor-mediated mechanism to induce antinociception. |
| doi_str_mv | 10.1016/j.euroneuro.2007.06.008 |
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The present study was conducted to determine whether these occur within the same brain site. Mice were stereotaxically implanted with microinjection cannulae in the periaqueductal gray (PAG) area of the midbrain. In saline-pretreated mice, exposure to 70% N2 O resulted in a concentration-dependent antinociceptive effect in the mouse abdominal constriction test. Pretreatment with an opioid antagonist in the PAG significantly antagonized the antinociceptive effect. Pretreatment with an inhibitor of NO production in the PAG also significantly antagonized the antinociceptive effect. These findings suggest that N2 O acts in the PAG via an NO-dependent, opioid receptor-mediated mechanism to induce antinociception.</description><identifier>ISSN: 0924-977X</identifier><identifier>EISSN: 1873-7862</identifier><identifier>DOI: 10.1016/j.euroneuro.2007.06.008</identifier><identifier>PMID: 17683915</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Analgesics, Non-Narcotic - pharmacology ; Animals ; Antinociception ; Dose-Response Relationship, Drug ; Internal Medicine ; Male ; Mesencephalon - drug effects ; Mesencephalon - metabolism ; Mice ; Microinjections ; Naltrexone - analogs & derivatives ; Naltrexone - pharmacology ; Nitric oxide ; Nitric Oxide - physiology ; Nitrous oxide ; Nitrous Oxide - pharmacology ; Opioid receptors ; Pain Measurement - drug effects ; Periaqueductal gray ; Periaqueductal Gray - drug effects ; Periaqueductal Gray - metabolism ; Psychiatry ; Receptors, Opioid - drug effects</subject><ispartof>European neuropsychopharmacology, 2008-03, Vol.18 (3), p.194-199</ispartof><rights>Elsevier B.V. and ECNP</rights><rights>2007 Elsevier B.V. and ECNP</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c594t-982335d9a757c882a30fe4c0836f597ce6909935c0aadd8366c788c6836cdb5c3</citedby><cites>FETCH-LOGICAL-c594t-982335d9a757c882a30fe4c0836f597ce6909935c0aadd8366c788c6836cdb5c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.euroneuro.2007.06.008$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17683915$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Emmanouil, Dimitris E</creatorcontrib><creatorcontrib>Dickens, Andrea S</creatorcontrib><creatorcontrib>Heckert, Rick W</creatorcontrib><creatorcontrib>Ohgami, Yusuke</creatorcontrib><creatorcontrib>Chung, Eunhee</creatorcontrib><creatorcontrib>Han, Shujie</creatorcontrib><creatorcontrib>Quock, Raymond M</creatorcontrib><title>Nitrous oxide-antinociception is mediated by opioid receptors and nitric oxide in the periaqueductal gray region of the midbrain</title><title>European neuropsychopharmacology</title><addtitle>Eur Neuropsychopharmacol</addtitle><description>Abstract Previous studies have shown that nitrous oxide (N2 O)-induced antinociception is sensitive to antagonism by blockade of opioid receptors and also by inhibition of nitric oxide (NO) production. The present study was conducted to determine whether these occur within the same brain site. Mice were stereotaxically implanted with microinjection cannulae in the periaqueductal gray (PAG) area of the midbrain. In saline-pretreated mice, exposure to 70% N2 O resulted in a concentration-dependent antinociceptive effect in the mouse abdominal constriction test. Pretreatment with an opioid antagonist in the PAG significantly antagonized the antinociceptive effect. Pretreatment with an inhibitor of NO production in the PAG also significantly antagonized the antinociceptive effect. These findings suggest that N2 O acts in the PAG via an NO-dependent, opioid receptor-mediated mechanism to induce antinociception.</description><subject>Analgesics, Non-Narcotic - pharmacology</subject><subject>Animals</subject><subject>Antinociception</subject><subject>Dose-Response Relationship, Drug</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Mesencephalon - drug effects</subject><subject>Mesencephalon - metabolism</subject><subject>Mice</subject><subject>Microinjections</subject><subject>Naltrexone - analogs & derivatives</subject><subject>Naltrexone - pharmacology</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - physiology</subject><subject>Nitrous oxide</subject><subject>Nitrous Oxide - pharmacology</subject><subject>Opioid receptors</subject><subject>Pain Measurement - drug effects</subject><subject>Periaqueductal gray</subject><subject>Periaqueductal Gray - drug effects</subject><subject>Periaqueductal Gray - metabolism</subject><subject>Psychiatry</subject><subject>Receptors, Opioid - drug effects</subject><issn>0924-977X</issn><issn>1873-7862</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk1v1DAQhiMEokvhL4BP3BL8sYntS6WqKh9SBQdA4mZ57cl2lqwd7KRib_x0HHZVPk5cbMnzzjueeaaqXjDaMMq6V7sG5hTDcjScUtnQrqFUPahWTElRS9Xxh9WKar6utZRfzqonOe8oZa0Q-nF1xmSnhGbtqvrxHqcU50zid_RQ2zBhiA4djBPGQDCTPXi0E3iyOZA4YkRPEizxmDKxwZNQHNAdDQgGMt0CGSGh_TaDn91kB7JN9lCytotl7H8p9ug3yWJ4Wj3q7ZDh2ek-rz6_vv509ba--fDm3dXlTe1avZ5qrbgQrddWttIpxa2gPawdVaLrWy0ddJpqLVpHrfW-vHZOKuVKm53zm9aJ8-ri6DvOm9KSgzAlO5gx4d6mg4kWzd-RgLdmG-8M51IzyovBy5NBiqWzPJk9ZgfDYAOUARpZNIJ36yKUR6FLMecE_X0RRs1Cz-zMPT2z0DO0M4VeyXz-5x9_551wFcHlUQBlUncIyWSHEFxBVJhMxkf8jyIX_3i4AQM6O3yFA-RdnFMoIAwzmRtqPi5LtOwQlWV_BJXiJ6epyYc</recordid><startdate>20080301</startdate><enddate>20080301</enddate><creator>Emmanouil, Dimitris E</creator><creator>Dickens, Andrea S</creator><creator>Heckert, Rick W</creator><creator>Ohgami, Yusuke</creator><creator>Chung, Eunhee</creator><creator>Han, Shujie</creator><creator>Quock, Raymond M</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20080301</creationdate><title>Nitrous oxide-antinociception is mediated by opioid receptors and nitric oxide in the periaqueductal gray region of the midbrain</title><author>Emmanouil, Dimitris E ; Dickens, Andrea S ; Heckert, Rick W ; Ohgami, Yusuke ; Chung, Eunhee ; Han, Shujie ; Quock, Raymond M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c594t-982335d9a757c882a30fe4c0836f597ce6909935c0aadd8366c788c6836cdb5c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Analgesics, Non-Narcotic - pharmacology</topic><topic>Animals</topic><topic>Antinociception</topic><topic>Dose-Response Relationship, Drug</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Mesencephalon - drug effects</topic><topic>Mesencephalon - metabolism</topic><topic>Mice</topic><topic>Microinjections</topic><topic>Naltrexone - analogs & derivatives</topic><topic>Naltrexone - pharmacology</topic><topic>Nitric oxide</topic><topic>Nitric Oxide - physiology</topic><topic>Nitrous oxide</topic><topic>Nitrous Oxide - pharmacology</topic><topic>Opioid receptors</topic><topic>Pain Measurement - drug effects</topic><topic>Periaqueductal gray</topic><topic>Periaqueductal Gray - drug effects</topic><topic>Periaqueductal Gray - metabolism</topic><topic>Psychiatry</topic><topic>Receptors, Opioid - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Emmanouil, Dimitris E</creatorcontrib><creatorcontrib>Dickens, Andrea S</creatorcontrib><creatorcontrib>Heckert, Rick W</creatorcontrib><creatorcontrib>Ohgami, Yusuke</creatorcontrib><creatorcontrib>Chung, Eunhee</creatorcontrib><creatorcontrib>Han, Shujie</creatorcontrib><creatorcontrib>Quock, Raymond M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European neuropsychopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Emmanouil, Dimitris E</au><au>Dickens, Andrea S</au><au>Heckert, Rick W</au><au>Ohgami, Yusuke</au><au>Chung, Eunhee</au><au>Han, Shujie</au><au>Quock, Raymond M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nitrous oxide-antinociception is mediated by opioid receptors and nitric oxide in the periaqueductal gray region of the midbrain</atitle><jtitle>European neuropsychopharmacology</jtitle><addtitle>Eur Neuropsychopharmacol</addtitle><date>2008-03-01</date><risdate>2008</risdate><volume>18</volume><issue>3</issue><spage>194</spage><epage>199</epage><pages>194-199</pages><issn>0924-977X</issn><eissn>1873-7862</eissn><abstract>Abstract Previous studies have shown that nitrous oxide (N2 O)-induced antinociception is sensitive to antagonism by blockade of opioid receptors and also by inhibition of nitric oxide (NO) production. The present study was conducted to determine whether these occur within the same brain site. Mice were stereotaxically implanted with microinjection cannulae in the periaqueductal gray (PAG) area of the midbrain. In saline-pretreated mice, exposure to 70% N2 O resulted in a concentration-dependent antinociceptive effect in the mouse abdominal constriction test. Pretreatment with an opioid antagonist in the PAG significantly antagonized the antinociceptive effect. Pretreatment with an inhibitor of NO production in the PAG also significantly antagonized the antinociceptive effect. These findings suggest that N2 O acts in the PAG via an NO-dependent, opioid receptor-mediated mechanism to induce antinociception.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>17683915</pmid><doi>10.1016/j.euroneuro.2007.06.008</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Analgesics, Non-Narcotic - pharmacology Animals Antinociception Dose-Response Relationship, Drug Internal Medicine Male Mesencephalon - drug effects Mesencephalon - metabolism Mice Microinjections Naltrexone - analogs & derivatives Naltrexone - pharmacology Nitric oxide Nitric Oxide - physiology Nitrous oxide Nitrous Oxide - pharmacology Opioid receptors Pain Measurement - drug effects Periaqueductal gray Periaqueductal Gray - drug effects Periaqueductal Gray - metabolism Psychiatry Receptors, Opioid - drug effects |
| title | Nitrous oxide-antinociception is mediated by opioid receptors and nitric oxide in the periaqueductal gray region of the midbrain |
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