Activation of NADPH oxidase-related proton and electron currents in human eosinophils by arachidonic acid

Effects of arachidonic acid (AA) on proton and electron currents in human eosinophils were studied using the permeabilized-patch voltage-clamp technique, using an applied NH 4 + gradient to control pH i . Superoxide anion (O 2 − ) release was assessed by cytochrome c reduction in human eosinophils...

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Veröffentlicht in:	The Journal of physiology 2001-09, Vol.535 (3), p.783-794
Hauptverfasser:	Cherny, V. V., Henderson, L. M., Xu, W., Thomas, L. L., DeCoursey, T. E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Arachidonic Acid - pharmacology Dose-Response Relationship, Drug Electrons Eosinophils - drug effects Eosinophils - metabolism Humans In Vitro Techniques Ion Channel Gating - drug effects Ion Channels - agonists NADPH Oxidases - physiology Original Oxygen Consumption - drug effects Protons Stimulation, Chemical
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