The consequences of disrupting cardiac inwardly rectifying K+ current (IK1) as revealed by the targeted deletion of the murine Kir2.1 and Kir2.2 genes

Ventricular myocytes demonstrate a steeply inwardly rectifying K + current termed I K1 . We investigated the molecular basis for murine I K1 by removing the genes encoding Kir2.1 and Kir2.2. The physiological consequences of the loss of these genes were studied in newborn animals because mice lackin...

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