Myoadenylate deaminase deficiency does not affect muscle anaplerosis during exhaustive exercise in humans

Myoadenylate deaminase (AMPD) deficiency is present in 1â2 % of the population. In theory, this deficiency may alter exercise energy metabolism by impairing the purine nucleotide cycle (PNC) and reducing tricarboxylic acid (TCA) cycle anaplerosis. The role of the PNC in TCA cycle anaplerosis is st...

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Veröffentlicht in:	The Journal of physiology 2001-06, Vol.533 (3), p.881-889
Hauptverfasser:	Tarnopolsky, Mark A., Parise, Gianni, Gibala, Martin J., Graham, Terry E., Rush, James W. E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Amino Acids - metabolism AMP Deaminase - deficiency Citric Acid Cycle - physiology Creatine - metabolism Energy Metabolism Exercise - physiology Exercise Test Humans Muscle, Skeletal - metabolism Muscle, Skeletal - physiopathology Nucleosides - metabolism Nucleotides - metabolism Original Phosphocreatine - metabolism Physical Endurance
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