The effects of capsaicin and acidity on currents generated by noxious heat in cultured neonatal rat dorsal root ganglion neurones

The effects of capsaicin, acidic pH, ATP, kainate and GABA on currents generated by noxious heat were studied in cultured dorsal root ganglion (DRG) neurones (< 20 Î¼m in diameter) isolated from neonatal rats. The patch clamp technique was used to record membrane currents or changes of membrane p...

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Veröffentlicht in:	The Journal of physiology 2001-06, Vol.533 (3), p.717-728
Hauptverfasser:	Vlachová, V., Lyfenko, A., Orkand, R. K., Vyklický, L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids - pharmacology Adenosine Triphosphate - pharmacology Animals Capsaicin - pharmacology Cells, Cultured Electric Conductivity Extracellular Space - metabolism Ganglia, Spinal - cytology Ganglia, Spinal - drug effects Ganglia, Spinal - physiology Hot Temperature Hydrogen-Ion Concentration Kainic Acid - pharmacology Neurons, Afferent - drug effects Neurons, Afferent - physiology Nociceptors - physiology Original Patch-Clamp Techniques Rats
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