Vascular endothelial growth factor increases Rana vascular permeability and compliance by different signalling pathways

Vascular endothelial growth factor (VEGF) chronically increases microvascular permeability, compliance and vessel diameter. To determine the signalling pathways by which VEGF exerts these effects, we investigated the role of Ca 2+ influx and mitogen-activated protein kinase (MAPK) phosphorylation on...

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Veröffentlicht in:	The Journal of physiology 2001-05, Vol.533 (1), p.263-272
Hauptverfasser:	Bates, D. O., Heald, R. I., Curry, F. E., Williams, B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Animals Calcium - metabolism Capillary Permeability - drug effects Endothelial Growth Factors - pharmacology Enzyme Activation - drug effects Enzyme Activation - physiology Enzyme Inhibitors - pharmacology Flavonoids - pharmacology Lymphokines - pharmacology Male MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - physiology Mitogen-Activated Protein Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinases - metabolism Original Rana pipiens Rana temporaria Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors
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