Presynaptic function is altered in snake K+-depolarized motor nerve terminals containing compromised mitochondria

Presynaptic function was investigated at K + -stimulated motor nerve terminals in snake costocutaneous nerve muscle preparations exposed to carbonyl cyanide m -chlorophenylhydrazone (CCCP, 2 Î¼ m ), oligomycin (8 Î¼g ml â1 ) or CCCP and oligomycin together. Miniature endplate currents (MEPCs) were...

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Veröffentlicht in:	The Journal of physiology 2001-04, Vol.532 (1), p.217-227
Hauptverfasser:	Calupca, Michelle A., Prior, Chris, Merriam, Laura A., Hendricks, Gregory M., Parsons, Rodney L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Adenosine Triphosphate - metabolism Animals Calcium - metabolism Carbonyl Cyanide m-Chlorophenyl Hydrazone - pharmacology Colubridae - physiology Endocytosis Enzyme Inhibitors - pharmacology Fluorescent Dyes - metabolism Glucose - metabolism Mitochondria - metabolism Motor Endplate - metabolism Motor Endplate - physiology Motor Endplate - ultrastructure Muscle Fibers, Skeletal - drug effects Muscle Fibers, Skeletal - metabolism Muscle Fibers, Skeletal - physiology Muscle, Skeletal - cytology Muscle, Skeletal - innervation Oligomycins - pharmacology Original Patch-Clamp Techniques Potassium - metabolism Propionates - pharmacology Pyridinium Compounds - metabolism Quaternary Ammonium Compounds - metabolism Synaptic Vesicles - physiology Uncoupling Agents - pharmacology
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