Functional inhibition of native volume-sensitive outwardly rectifying anion channels in muscle cells and Xenopus oocytes by anti-ClC-3 antibody

Intracellular dialysis of NIH/3T3 cells with a commercially available anti-ClC-3 polyclonal antibody (Ab) for â30 min completely inhibited expressed guinea-pig ClC-3 currents ( I gpClC-3 ), while intracellular dialysis with antigen-preabsorbed anti-ClC-3 Ab failed to affect I gpClC-3 . Anti-ClC-3...

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Veröffentlicht in:	The Journal of physiology 2001-03, Vol.531 (2), p.437-444
Hauptverfasser:	Duan, Dayue, Zhong, Juming, Hermoso, Marcela, Satterwhite, Christina M., Rossow, Charles F., Hatton, William J., Ilia Yamboliev, Horowitz, Burton, Hume, Joseph R.
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animals Anions - metabolism Antibodies - pharmacology Chloride Channels - immunology Female Freshwater Injections Ion Channels - antagonists & inhibitors Mice Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - metabolism Myocardium - cytology Myocardium - metabolism Oocytes - metabolism Rapid Report Xenopus laevis
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