Genetic analysis of the role of peroxisomes in the utilization of acetate and fatty acids in Aspergillus nidulans
Peroxisomes are organelles containing a diverse array of enzymes. In fungi they are important for carbon source utilization, pathogenesis, development, and secondary metabolism. We have studied Aspergillus nidulans peroxin (pex) mutants isolated by virtue of their inability to grow on butyrate or by...
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| Veröffentlicht in: | Genetics (Austin) 2008-03, Vol.178 (3), p.1355-1369 |
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| description | Peroxisomes are organelles containing a diverse array of enzymes. In fungi they are important for carbon source utilization, pathogenesis, development, and secondary metabolism. We have studied Aspergillus nidulans peroxin (pex) mutants isolated by virtue of their inability to grow on butyrate or by the inactivation of specific pex genes. While all pex mutants are able to form colonies, those unable to import PTS1 proteins are partially defective in asexual and sexual development. The pex mutants are able to grow on acetate but are affected in growth on fatty acids, indicating a requirement for the peroxisomal localization of beta-oxidation enzymes. However, mislocalization of malate synthase does not prevent growth on either fatty acids or acetate, showing that the glyoxylate cycle does not require peroxisomal localization. Proliferation of peroxisomes is dependent on fatty acids, but not on acetate, and on PexK (Pex11), expression of which is activated by the FarA transcription factor. Proliferation was greatly reduced in a farADelta strain. A mutation affecting a mitochodrial ketoacyl-CoA thiolase and disruption of a mitochondrial hydroxy-acyl-CoA dehydrogenase gene prevented growth on short-chain but not long-chain fatty acids. Together with previous results, this is consistent with growth on even-numbered short-chain fatty acids requiring a mitochondrial as well as a peroxisomal beta-oxidation pathway. The mitochondrial pathway is not required for growth on valerate or for long-chain fatty acid utilization. |
| doi_str_mv | 10.1534/genetics.107.085795 |
| format | Article |
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In fungi they are important for carbon source utilization, pathogenesis, development, and secondary metabolism. We have studied Aspergillus nidulans peroxin (pex) mutants isolated by virtue of their inability to grow on butyrate or by the inactivation of specific pex genes. While all pex mutants are able to form colonies, those unable to import PTS1 proteins are partially defective in asexual and sexual development. The pex mutants are able to grow on acetate but are affected in growth on fatty acids, indicating a requirement for the peroxisomal localization of beta-oxidation enzymes. However, mislocalization of malate synthase does not prevent growth on either fatty acids or acetate, showing that the glyoxylate cycle does not require peroxisomal localization. Proliferation of peroxisomes is dependent on fatty acids, but not on acetate, and on PexK (Pex11), expression of which is activated by the FarA transcription factor. Proliferation was greatly reduced in a farADelta strain. A mutation affecting a mitochodrial ketoacyl-CoA thiolase and disruption of a mitochondrial hydroxy-acyl-CoA dehydrogenase gene prevented growth on short-chain but not long-chain fatty acids. Together with previous results, this is consistent with growth on even-numbered short-chain fatty acids requiring a mitochondrial as well as a peroxisomal beta-oxidation pathway. The mitochondrial pathway is not required for growth on valerate or for long-chain fatty acid utilization.</description><identifier>ISSN: 0016-6731</identifier><identifier>ISSN: 1943-2631</identifier><identifier>EISSN: 1943-2631</identifier><identifier>DOI: 10.1534/genetics.107.085795</identifier><identifier>PMID: 18245820</identifier><identifier>CODEN: GENTAE</identifier><language>eng</language><publisher>United States: Genetics Soc America</publisher><subject>Acetates - metabolism ; acetic acid ; Aspergillus nidulans - cytology ; Aspergillus nidulans - genetics ; Aspergillus nidulans - growth & development ; Aspergillus nidulans - metabolism ; Aspergillus nidulellus ; Carbon - pharmacology ; Ethanol ; Fatty acids ; Fatty Acids - metabolism ; fungal proteins ; Fungal Proteins - isolation & purification ; Fungal Proteins - metabolism ; gene expression ; hydroxy-acyl-CoA dehydrogenase ; Investigations ; ketoacyl-CoA thiolase ; lipid metabolism ; metabolism ; Mitochondria - drug effects ; Mitochondria - metabolism ; Mutant Proteins - isolation & purification ; Mutant Proteins - metabolism ; Mutation - genetics ; peroxin ; peroxisomes ; Peroxisomes - drug effects ; Peroxisomes - genetics ; Peroxisomes - metabolism ; Phenotype ; Protein Transport - drug effects ; Proteins ; PTS1 protein ; Spores, Fungal - drug effects ; transcription factors</subject><ispartof>Genetics (Austin), 2008-03, Vol.178 (3), p.1355-1369</ispartof><rights>Copyright Genetics Society of America Mar 2008</rights><rights>Copyright © 2008 by the Genetics Society of America</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c552t-8a7b7529220050337063066653afa6bd10e112aefa84ab75abcdbeca9f78f7433</citedby><cites>FETCH-LOGICAL-c552t-8a7b7529220050337063066653afa6bd10e112aefa84ab75abcdbeca9f78f7433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,782,786,887,27933,27934</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18245820$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hynes, M.J</creatorcontrib><creatorcontrib>Murray, S.L</creatorcontrib><creatorcontrib>Khew, G.S</creatorcontrib><creatorcontrib>Davis, M.A</creatorcontrib><title>Genetic analysis of the role of peroxisomes in the utilization of acetate and fatty acids in Aspergillus nidulans</title><title>Genetics (Austin)</title><addtitle>Genetics</addtitle><description>Peroxisomes are organelles containing a diverse array of enzymes. In fungi they are important for carbon source utilization, pathogenesis, development, and secondary metabolism. We have studied Aspergillus nidulans peroxin (pex) mutants isolated by virtue of their inability to grow on butyrate or by the inactivation of specific pex genes. While all pex mutants are able to form colonies, those unable to import PTS1 proteins are partially defective in asexual and sexual development. The pex mutants are able to grow on acetate but are affected in growth on fatty acids, indicating a requirement for the peroxisomal localization of beta-oxidation enzymes. However, mislocalization of malate synthase does not prevent growth on either fatty acids or acetate, showing that the glyoxylate cycle does not require peroxisomal localization. Proliferation of peroxisomes is dependent on fatty acids, but not on acetate, and on PexK (Pex11), expression of which is activated by the FarA transcription factor. Proliferation was greatly reduced in a farADelta strain. A mutation affecting a mitochodrial ketoacyl-CoA thiolase and disruption of a mitochondrial hydroxy-acyl-CoA dehydrogenase gene prevented growth on short-chain but not long-chain fatty acids. Together with previous results, this is consistent with growth on even-numbered short-chain fatty acids requiring a mitochondrial as well as a peroxisomal beta-oxidation pathway. The mitochondrial pathway is not required for growth on valerate or for long-chain fatty acid utilization.</description><subject>Acetates - metabolism</subject><subject>acetic acid</subject><subject>Aspergillus nidulans - cytology</subject><subject>Aspergillus nidulans - genetics</subject><subject>Aspergillus nidulans - growth & development</subject><subject>Aspergillus nidulans - metabolism</subject><subject>Aspergillus nidulellus</subject><subject>Carbon - pharmacology</subject><subject>Ethanol</subject><subject>Fatty acids</subject><subject>Fatty Acids - metabolism</subject><subject>fungal proteins</subject><subject>Fungal Proteins - isolation & purification</subject><subject>Fungal Proteins - metabolism</subject><subject>gene expression</subject><subject>hydroxy-acyl-CoA dehydrogenase</subject><subject>Investigations</subject><subject>ketoacyl-CoA thiolase</subject><subject>lipid metabolism</subject><subject>metabolism</subject><subject>Mitochondria - drug effects</subject><subject>Mitochondria - metabolism</subject><subject>Mutant Proteins - isolation & purification</subject><subject>Mutant Proteins - metabolism</subject><subject>Mutation - genetics</subject><subject>peroxin</subject><subject>peroxisomes</subject><subject>Peroxisomes - drug effects</subject><subject>Peroxisomes - genetics</subject><subject>Peroxisomes - metabolism</subject><subject>Phenotype</subject><subject>Protein Transport - drug effects</subject><subject>Proteins</subject><subject>PTS1 protein</subject><subject>Spores, Fungal - drug effects</subject><subject>transcription factors</subject><issn>0016-6731</issn><issn>1943-2631</issn><issn>1943-2631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkU1v1DAQhiMEokvhFyBBxAFOWcZ2_JELUlVBQarEAXq2JomTdeWNt7bDsvx6vM3yebI187yvZ_wWxXMCa8JZ_XY0k0m2i2sCcg2Ky4Y_KFakqVlFBSMPixUAEZWQjJwVT2K8BQDRcPW4OCOK1lxRWBV3V4tLiRO6Q7Sx9EOZNqYM3pnjfWeC_26j35pY2um-NSfr7A9M1k9HAjuTMJns0JcDpnTIFdvf0xcxy0fr3BzLyfazwyk-LR4N6KJ5djrPi5sP779efqyuP199ury4rjrOaaoUylZy2lAKwIExCYKBEIIzHFC0PQFDCEUzoKoxk9h2fWs6bAapBlkzdl68W3x3c7s1fWemFNDpXbBbDAft0ep_O5Pd6NF_05RKlR_LBq9PBsHfzSYmvbWxMy4vYfwctYRa0JxEBl_9B976OeT_jJqSmjCgUmaILVAXfIzBDL8nIaCPeepfeeaC1EueWfXi7yX-aE4BZuDNAmzsuNnbYHTconMZJ3q_3xOpNNOE8aPVy4Uc0Gscg4365guFPB40UDMl2E8XxLbz</recordid><startdate>20080301</startdate><enddate>20080301</enddate><creator>Hynes, M.J</creator><creator>Murray, S.L</creator><creator>Khew, G.S</creator><creator>Davis, M.A</creator><general>Genetics Soc America</general><general>Genetics Society of America</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4T-</scope><scope>4U-</scope><scope>7QP</scope><scope>7SS</scope><scope>7TK</scope><scope>7TM</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20080301</creationdate><title>Genetic analysis of the role of peroxisomes in the utilization of acetate and fatty acids in Aspergillus nidulans</title><author>Hynes, M.J ; Murray, S.L ; Khew, G.S ; Davis, M.A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c552t-8a7b7529220050337063066653afa6bd10e112aefa84ab75abcdbeca9f78f7433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Acetates - metabolism</topic><topic>acetic acid</topic><topic>Aspergillus nidulans - cytology</topic><topic>Aspergillus nidulans - genetics</topic><topic>Aspergillus nidulans - growth & development</topic><topic>Aspergillus nidulans - metabolism</topic><topic>Aspergillus nidulellus</topic><topic>Carbon - pharmacology</topic><topic>Ethanol</topic><topic>Fatty acids</topic><topic>Fatty Acids - metabolism</topic><topic>fungal proteins</topic><topic>Fungal Proteins - isolation & purification</topic><topic>Fungal Proteins - metabolism</topic><topic>gene expression</topic><topic>hydroxy-acyl-CoA dehydrogenase</topic><topic>Investigations</topic><topic>ketoacyl-CoA thiolase</topic><topic>lipid metabolism</topic><topic>metabolism</topic><topic>Mitochondria - drug effects</topic><topic>Mitochondria - metabolism</topic><topic>Mutant Proteins - isolation & purification</topic><topic>Mutant Proteins - metabolism</topic><topic>Mutation - genetics</topic><topic>peroxin</topic><topic>peroxisomes</topic><topic>Peroxisomes - drug effects</topic><topic>Peroxisomes - genetics</topic><topic>Peroxisomes - metabolism</topic><topic>Phenotype</topic><topic>Protein Transport - drug effects</topic><topic>Proteins</topic><topic>PTS1 protein</topic><topic>Spores, Fungal - drug effects</topic><topic>transcription factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hynes, M.J</creatorcontrib><creatorcontrib>Murray, S.L</creatorcontrib><creatorcontrib>Khew, G.S</creatorcontrib><creatorcontrib>Davis, M.A</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>University Readers</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>Proquest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Genetics (Austin)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hynes, M.J</au><au>Murray, S.L</au><au>Khew, G.S</au><au>Davis, M.A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic analysis of the role of peroxisomes in the utilization of acetate and fatty acids in Aspergillus nidulans</atitle><jtitle>Genetics (Austin)</jtitle><addtitle>Genetics</addtitle><date>2008-03-01</date><risdate>2008</risdate><volume>178</volume><issue>3</issue><spage>1355</spage><epage>1369</epage><pages>1355-1369</pages><issn>0016-6731</issn><issn>1943-2631</issn><eissn>1943-2631</eissn><coden>GENTAE</coden><abstract>Peroxisomes are organelles containing a diverse array of enzymes. In fungi they are important for carbon source utilization, pathogenesis, development, and secondary metabolism. We have studied Aspergillus nidulans peroxin (pex) mutants isolated by virtue of their inability to grow on butyrate or by the inactivation of specific pex genes. While all pex mutants are able to form colonies, those unable to import PTS1 proteins are partially defective in asexual and sexual development. The pex mutants are able to grow on acetate but are affected in growth on fatty acids, indicating a requirement for the peroxisomal localization of beta-oxidation enzymes. However, mislocalization of malate synthase does not prevent growth on either fatty acids or acetate, showing that the glyoxylate cycle does not require peroxisomal localization. Proliferation of peroxisomes is dependent on fatty acids, but not on acetate, and on PexK (Pex11), expression of which is activated by the FarA transcription factor. Proliferation was greatly reduced in a farADelta strain. A mutation affecting a mitochodrial ketoacyl-CoA thiolase and disruption of a mitochondrial hydroxy-acyl-CoA dehydrogenase gene prevented growth on short-chain but not long-chain fatty acids. Together with previous results, this is consistent with growth on even-numbered short-chain fatty acids requiring a mitochondrial as well as a peroxisomal beta-oxidation pathway. The mitochondrial pathway is not required for growth on valerate or for long-chain fatty acid utilization.</abstract><cop>United States</cop><pub>Genetics Soc America</pub><pmid>18245820</pmid><doi>10.1534/genetics.107.085795</doi><tpages>15</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Genetics (Austin), 2008-03, Vol.178 (3), p.1355-1369 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Acetates - metabolism acetic acid Aspergillus nidulans - cytology Aspergillus nidulans - genetics Aspergillus nidulans - growth & development Aspergillus nidulans - metabolism Aspergillus nidulellus Carbon - pharmacology Ethanol Fatty acids Fatty Acids - metabolism fungal proteins Fungal Proteins - isolation & purification Fungal Proteins - metabolism gene expression hydroxy-acyl-CoA dehydrogenase Investigations ketoacyl-CoA thiolase lipid metabolism metabolism Mitochondria - drug effects Mitochondria - metabolism Mutant Proteins - isolation & purification Mutant Proteins - metabolism Mutation - genetics peroxin peroxisomes Peroxisomes - drug effects Peroxisomes - genetics Peroxisomes - metabolism Phenotype Protein Transport - drug effects Proteins PTS1 protein Spores, Fungal - drug effects transcription factors |
| title | Genetic analysis of the role of peroxisomes in the utilization of acetate and fatty acids in Aspergillus nidulans |
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