Exosomal Fetuin-A identified by proteomics: A novel urinary biomarker for detecting acute kidney injury

Urinary exosomes containing apical membrane and intracellular fluid are normally secreted into the urine from all nephron segments, and may carry protein markers of renal dysfunction and structural injury. We aimed to discover biomarkers in urinary exosomes to detect acute kidney injury (AKI), which...

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Veröffentlicht in:	Kidney international 2006-11, Vol.70 (10), p.1847-1857
Hauptverfasser:	Zhou, H., Pisitkun, T., Aponte, A., Yuen, P.S.T., Hoffert, J.D., Yasuda, H., Hu, X., Chawla, L., Shen, R.-F., Knepper, M.A., Star, R.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Kidney Injury - etiology Acute Kidney Injury - pathology Acute Kidney Injury - urine Adult Aged Aged, 80 and over AKI alpha-2-HS-Glycoprotein alpha-Fetoproteins - urine Animals Antineoplastic Agents - adverse effects Antineoplastic Agents - pharmacology Bacterial diseases Bacterial sepsis Biological and medical sciences Biomarkers - urine Blood Proteins - urine Cell Membrane - metabolism cisplatin Cisplatin - adverse effects Cisplatin - pharmacology exosomes Female Human bacterial diseases Humans Infectious diseases ischemia Kidney - drug effects Kidney - injuries Kidney - pathology Kidneys Male mass spectrometry Medical sciences Middle Aged Models, Animal Nephrology. Urinary tract diseases Proteomics - methods Rats Reperfusion Injury - etiology Reperfusion Injury - pathology Reperfusion Injury - urine sepsis Urinary system involvement in other diseases. Miscellaneous
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