Compartmentalized NMDA receptor signalling to survival and death

The ability of Ca 2+ influx through the N -methyl d -aspartate subclass of glutamate receptor (NMDA receptor) to both kill neurons and to promote survival under different circumstances is well established. Here we discuss the signal pathways that mediate this dichotomous signalling, and the factors...

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Veröffentlicht in:	The Journal of physiology 2007-10, Vol.584 (2), p.381-387
Hauptverfasser:	Soriano, Francesc X., Hardingham, Giles E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Calcium Signaling - drug effects Cell Membrane - metabolism Cell Nucleus - metabolism Cell Survival Excitatory Amino Acid Antagonists - pharmacology Excitatory Amino Acid Antagonists - therapeutic use Humans Mitochondria - metabolism Neurons - drug effects Neurons - metabolism Neurons - pathology Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Receptors, N-Methyl-D-Aspartate - metabolism Stroke - drug therapy Stroke - metabolism Symposium Section Reports: Compartmentalized Signalling In Neurons Time Factors Treatment Outcome
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