Regulation of Prolactin Receptor Levels and Activity in Breast Cancer
From its traditional identity as a hormone involved in growth and differentiation of mammary epithelium and in lactation, to having a pertinent role in the development of mammary carcinoma, the peptide hormone/cytokine prolactin (PRL) has emerged as a versatile signaling molecule. There has been sig...
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| Veröffentlicht in: | Journal of mammary gland biology and neoplasia 2008-03, Vol.13 (1), p.81-91 |
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| container_title | Journal of mammary gland biology and neoplasia |
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| creator | Swaminathan, G Varghese, B Fuchs, S. Y |
| description | From its traditional identity as a hormone involved in growth and differentiation of mammary epithelium and in lactation, to having a pertinent role in the development of mammary carcinoma, the peptide hormone/cytokine prolactin (PRL) has emerged as a versatile signaling molecule. There has been significant progress in our understanding of the fine working of PRL in the past several years. Notably, much effort has been concentrated on the mediator of PRL action, namely, the prolactin receptor (PRLr). The causal link between increased PRLr expression and breast cancer is being increasingly appreciated. Considering that the level of the receptor on the surface is a critical determinant of signaling output in response to PRL, the uncovering of regulatory elements that control receptor expression becomes important. The principle focus of this review is on the regulation of PRLr expression and activity in breast cancer with a brief overview of different isoforms of PRLr, their expression, signaling capabilities and the biological outcomes of PRL/PRLr signaling. |
| doi_str_mv | 10.1007/s10911-008-9068-6 |
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Y</creatorcontrib><title>Regulation of Prolactin Receptor Levels and Activity in Breast Cancer</title><title>Journal of mammary gland biology and neoplasia</title><addtitle>J Mammary Gland Biol Neoplasia</addtitle><addtitle>J Mammary Gland Biol Neoplasia</addtitle><description>From its traditional identity as a hormone involved in growth and differentiation of mammary epithelium and in lactation, to having a pertinent role in the development of mammary carcinoma, the peptide hormone/cytokine prolactin (PRL) has emerged as a versatile signaling molecule. There has been significant progress in our understanding of the fine working of PRL in the past several years. Notably, much effort has been concentrated on the mediator of PRL action, namely, the prolactin receptor (PRLr). The causal link between increased PRLr expression and breast cancer is being increasingly appreciated. Considering that the level of the receptor on the surface is a critical determinant of signaling output in response to PRL, the uncovering of regulatory elements that control receptor expression becomes important. The principle focus of this review is on the regulation of PRLr expression and activity in breast cancer with a brief overview of different isoforms of PRLr, their expression, signaling capabilities and the biological outcomes of PRL/PRLr signaling.</description><subject>Animals</subject><subject>Breast cancer</subject><subject>breast neoplasms</subject><subject>Breast Neoplasms - genetics</subject><subject>Breast Neoplasms - metabolism</subject><subject>Cancer Research</subject><subject>endocytosis</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Oncology</subject><subject>Prolactin receptor</subject><subject>Protein Isoforms - chemistry</subject><subject>Protein Isoforms - metabolism</subject><subject>Receptors, Prolactin - chemistry</subject><subject>Receptors, Prolactin - genetics</subject><subject>Receptors, Prolactin - metabolism</subject><subject>Regulation</subject><subject>Signal Transduction</subject><subject>Signaling</subject><subject>Ubiquitin - metabolism</subject><subject>Ubiquitination</subject><issn>1083-3021</issn><issn>1573-7039</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU9v1DAQxS1ERf_AB-DSRhx6C4zHjmNfkMqqBaSVQKWcLSc7WVJl7a2drNRvX1dZUcqhJ1t6v_c848fYew4fOUD9KXEwnJcAujSgdKlesSNe1aKsQZjX-Q5alAKQH7LjlG4BwGhVvWGHXCNIo_GIXV7Tehrc2AdfhK74GcPg2rH3xTW1tB1DLJa0oyEVzq-Ki6zs-vG-yPqXSC6NxcL5luJbdtC5IdG7_XnCbq4ubxbfyuWPr98XF8uylYaPJZKTumtkJXgNlRHYAFYkpZDYmJpIipVGXFGlWlKNMkYZ16BA1ZAQjRAn7PMcu52aDa1a8mN0g93GfuPivQ2ut88V3_-x67CziLVSaHLA-T4ghruJ0mg3fWppGJynMCWb_01ybnQGP_wH3oYp-rybRW5QaF7XGeIz1MaQUqTu7yQc7GNBdi7I5oLsY0FWZc_pvys8OfaNZABnIGXJryk-vfxS6tls6lywbh37ZH__QuAiM0pqheIBCMKj2w</recordid><startdate>20080301</startdate><enddate>20080301</enddate><creator>Swaminathan, G</creator><creator>Varghese, B</creator><creator>Fuchs, S. 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| ispartof | Journal of mammary gland biology and neoplasia, 2008-03, Vol.13 (1), p.81-91 |
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| subjects | Animals Breast cancer breast neoplasms Breast Neoplasms - genetics Breast Neoplasms - metabolism Cancer Research endocytosis Gene Expression Regulation, Neoplastic Humans Medicine Medicine & Public Health Oncology Prolactin receptor Protein Isoforms - chemistry Protein Isoforms - metabolism Receptors, Prolactin - chemistry Receptors, Prolactin - genetics Receptors, Prolactin - metabolism Regulation Signal Transduction Signaling Ubiquitin - metabolism Ubiquitination |
| title | Regulation of Prolactin Receptor Levels and Activity in Breast Cancer |
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