Erythropoietin receptor transcription is neither elevated nor predictive of surface expression in human tumour cells

Erythropoietin receptor (EpoR) has been reported to be overexpressed in tumours and has raised safety concerns regarding the use of erythropoiesis-stimulating agents (ESAs) to treat anaemia in cancer patients. To investigate the potential for EpoR to be overexpressed in tumours, we have evaluated hu...

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Veröffentlicht in:	British journal of cancer 2008-03, Vol.98 (6), p.1059-1067
Hauptverfasser:	Sinclair, A M, Rogers, N, Busse, L, Archibeque, I, Brown, W, Kassner, P D, Watson, J E V, Arnold, G E, Nguyen, K C Q, Powers, S, Elliott, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Anemia Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Cell Line Drug Resistance Epidemiology Gene Amplification Humans Medical research Medical sciences Molecular Medicine Neoplasms - genetics Oligonucleotide Array Sequence Analysis Oncology Polyclonal antibodies Proteins Receptors, Erythropoietin - genetics Receptors, Erythropoietin - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - analysis Transcription, Genetic Translational Therapeutics Tumors
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