Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer

Although mutation of APC or CTNNB1 ( β -catenin) is rare in breast cancer, activation of Wnt signalling is nonetheless thought to play an important role in breast tumorigenesis, and epigenetic silencing of Wnt antagonist genes, including the secreted frizzled-related protein (SFRP) and Dickkopf (DKK...

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Veröffentlicht in:	British journal of cancer 2008-03, Vol.98 (6), p.1147-1156
Hauptverfasser:	Suzuki, H, Toyota, M, Caraway, H, Gabrielson, E, Ohmura, T, Fujikane, T, Nishikawa, N, Sogabe, Y, Nojima, M, Sonoda, T, Mori, M, Hirata, K, Imai, K, Shinomura, Y, Baylin, S B, Tokino, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biomedical and Life Sciences Biomedicine Breast cancer Breast Neoplasms - genetics Cancer Research Cell Line, Tumor DNA Methylation Drug Resistance Epidemiology Epigenesis, Genetic Eye Proteins - genetics Female Gene Silencing Genes, Tumor Suppressor Genetics and Genomics Gynecology. Andrology. Obstetrics Humans Intercellular Signaling Peptides and Proteins - genetics Mammary gland diseases Medical sciences Membrane Proteins - genetics Molecular Medicine Oncology Tumors Wnt Proteins - physiology
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