Involvement of tumour necrosis factor‐α in Clostridium perfringensβ‐toxin‐induced plasma extravasation in mice

Background and purpose: Clostridium perfringens beta‐toxin, an important agent of necrotic enteritis, causes plasma extravasation due to the release of a tachykinin NK1 receptor agonist in mouse skin. In this study, we investigated the role of cytokines in beta‐toxin‐induced plasma extravasation. Ex...

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Veröffentlicht in:	British journal of pharmacology 2008-03, Vol.153 (6), p.1296-1302
Hauptverfasser:	Nagahama, M, Kihara, A, Kintoh, H, Oda, M, Sakurai, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacterial Toxins - administration & dosage Bacterial Toxins - pharmacology Bacterial Toxins - toxicity beta‐toxin Biological and medical sciences Clostridium perfringens Dose-Response Relationship, Drug Enzyme-Linked Immunosorbent Assay Interleukin-1beta - drug effects Interleukin-1beta - metabolism Male Medical sciences Mice Mice, Inbred BALB C Mice, Inbred C3H Pharmacology. Drug treatments Plasma - drug effects Plasma - metabolism plasma extravasation Receptors, Neurokinin-1 - drug effects Receptors, Neurokinin-1 - metabolism Research Papers Skin - drug effects Skin - metabolism tachykinin NK1 receptor TNF‐α Toll-Like Receptor 4 - drug effects Toll-Like Receptor 4 - metabolism Tumor Necrosis Factor-alpha - drug effects Tumor Necrosis Factor-alpha - metabolism
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