possible new inherited myopathy in a young Labrador retriever
A 5-month-old, male, Labrador retriever was evaluated for progressive weakness and muscle atrophy. Histologic evaluation of fresh frozen muscle revealed distinct cytoarchitectural changes and central mitochondrial accumulations indistinguishable from those found in the inherited myopathy described i...
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| Veröffentlicht in: | Canadian veterinary journal 2008-04, Vol.49 (4), p.393-397 |
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| container_title | Canadian veterinary journal |
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| creator | Cosford, K.L Taylor, S.M Thompson, L Shelton, G.D |
| description | A 5-month-old, male, Labrador retriever was evaluated for progressive weakness and muscle atrophy. Histologic evaluation of fresh frozen muscle revealed distinct cytoarchitectural changes and central mitochondrial accumulations indistinguishable from those found in the inherited myopathy described in Great Danes. Multiple male littermates and half-siblings were similarly affected. |
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Histologic evaluation of fresh frozen muscle revealed distinct cytoarchitectural changes and central mitochondrial accumulations indistinguishable from those found in the inherited myopathy described in Great Danes. Multiple male littermates and half-siblings were similarly affected.</description><identifier>ISSN: 0008-5286</identifier><identifier>PMID: 18481550</identifier><language>eng</language><publisher>Canada: Canadian Veterinary Medical Association</publisher><subject>animal pathology ; Animals ; atrophy ; case studies ; disease course ; disease diagnosis ; dog diseases ; Dog Diseases - diagnosis ; Dog Diseases - genetics ; Dogs ; Fatal Outcome ; genetic disorders ; histopathology ; Labrador Retriever ; leg weakness ; Male ; males ; microstructure ; mitochondria ; Muscle Weakness - etiology ; Muscle Weakness - veterinary ; muscles ; Muscular Atrophy - diagnosis ; Muscular Atrophy - genetics ; Muscular Atrophy - veterinary ; Muscular Diseases - diagnosis ; Muscular Diseases - genetics ; Muscular Diseases - veterinary ; puppies ; Scientific ; signs and symptoms (animals and humans)</subject><ispartof>Canadian veterinary journal, 2008-04, Vol.49 (4), p.393-397</ispartof><rights>Copyright and/or publishing rights held by the Canadian Veterinary Medical Association 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275345/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275345/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18481550$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cosford, K.L</creatorcontrib><creatorcontrib>Taylor, S.M</creatorcontrib><creatorcontrib>Thompson, L</creatorcontrib><creatorcontrib>Shelton, G.D</creatorcontrib><title>possible new inherited myopathy in a young Labrador retriever</title><title>Canadian veterinary journal</title><addtitle>Can Vet J</addtitle><description>A 5-month-old, male, Labrador retriever was evaluated for progressive weakness and muscle atrophy. Histologic evaluation of fresh frozen muscle revealed distinct cytoarchitectural changes and central mitochondrial accumulations indistinguishable from those found in the inherited myopathy described in Great Danes. Multiple male littermates and half-siblings were similarly affected.</description><subject>animal pathology</subject><subject>Animals</subject><subject>atrophy</subject><subject>case studies</subject><subject>disease course</subject><subject>disease diagnosis</subject><subject>dog diseases</subject><subject>Dog Diseases - diagnosis</subject><subject>Dog Diseases - genetics</subject><subject>Dogs</subject><subject>Fatal Outcome</subject><subject>genetic disorders</subject><subject>histopathology</subject><subject>Labrador Retriever</subject><subject>leg weakness</subject><subject>Male</subject><subject>males</subject><subject>microstructure</subject><subject>mitochondria</subject><subject>Muscle Weakness - etiology</subject><subject>Muscle Weakness - veterinary</subject><subject>muscles</subject><subject>Muscular Atrophy - diagnosis</subject><subject>Muscular Atrophy - genetics</subject><subject>Muscular Atrophy - veterinary</subject><subject>Muscular Diseases - diagnosis</subject><subject>Muscular Diseases - genetics</subject><subject>Muscular Diseases - veterinary</subject><subject>puppies</subject><subject>Scientific</subject><subject>signs and symptoms (animals and humans)</subject><issn>0008-5286</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkEtLxDAUhbtQnHH0L2hW7gp5tslCQQZfUHDhuA5JezsTaZuatCP99xZmFF1dOPfjO3BOkiXGWKaCymyRnMf4gTFVJMNnyYJILokQeJnc9j5GZxtAHXwh1-0guAEq1E6-N8NumiNk0OTHbosKY4OpfEABhuBgD-EiOa1NE-HyeFfJ5vFhs35Oi9enl_V9kdZUyiEV1lKSlZyUVnGOOQOoWMkkpryymKtMMZJVJpdU1FJljEvFbV5ZJQ3DJWOr5O6g7UfbQlVCNwTT6D641oRJe-P0_0_ndnrr95rSXDAuZsHNURD85whx0K2LJTSN6cCPUec4JyQXdAav_jb9VvwMNgPXB6A2XpttcFG_v1FM2Dy1EpxS9g1sgm_s</recordid><startdate>20080401</startdate><enddate>20080401</enddate><creator>Cosford, K.L</creator><creator>Taylor, S.M</creator><creator>Thompson, L</creator><creator>Shelton, G.D</creator><general>Canadian Veterinary Medical Association</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20080401</creationdate><title>possible new inherited myopathy in a young Labrador retriever</title><author>Cosford, K.L ; Taylor, S.M ; Thompson, L ; Shelton, G.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-f288t-5bb216c41cb944043eed3c38024db04969316da7825f89634894b7db98a30c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>animal pathology</topic><topic>Animals</topic><topic>atrophy</topic><topic>case studies</topic><topic>disease course</topic><topic>disease diagnosis</topic><topic>dog diseases</topic><topic>Dog Diseases - diagnosis</topic><topic>Dog Diseases - genetics</topic><topic>Dogs</topic><topic>Fatal Outcome</topic><topic>genetic disorders</topic><topic>histopathology</topic><topic>Labrador Retriever</topic><topic>leg weakness</topic><topic>Male</topic><topic>males</topic><topic>microstructure</topic><topic>mitochondria</topic><topic>Muscle Weakness - etiology</topic><topic>Muscle Weakness - veterinary</topic><topic>muscles</topic><topic>Muscular Atrophy - diagnosis</topic><topic>Muscular Atrophy - genetics</topic><topic>Muscular Atrophy - veterinary</topic><topic>Muscular Diseases - diagnosis</topic><topic>Muscular Diseases - genetics</topic><topic>Muscular Diseases - veterinary</topic><topic>puppies</topic><topic>Scientific</topic><topic>signs and symptoms (animals and humans)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cosford, K.L</creatorcontrib><creatorcontrib>Taylor, S.M</creatorcontrib><creatorcontrib>Thompson, L</creatorcontrib><creatorcontrib>Shelton, G.D</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Canadian veterinary journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cosford, K.L</au><au>Taylor, S.M</au><au>Thompson, L</au><au>Shelton, G.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>possible new inherited myopathy in a young Labrador retriever</atitle><jtitle>Canadian veterinary journal</jtitle><addtitle>Can Vet J</addtitle><date>2008-04-01</date><risdate>2008</risdate><volume>49</volume><issue>4</issue><spage>393</spage><epage>397</epage><pages>393-397</pages><issn>0008-5286</issn><abstract>A 5-month-old, male, Labrador retriever was evaluated for progressive weakness and muscle atrophy. Histologic evaluation of fresh frozen muscle revealed distinct cytoarchitectural changes and central mitochondrial accumulations indistinguishable from those found in the inherited myopathy described in Great Danes. Multiple male littermates and half-siblings were similarly affected.</abstract><cop>Canada</cop><pub>Canadian Veterinary Medical Association</pub><pmid>18481550</pmid><tpages>5</tpages></addata></record> |
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| ispartof | Canadian veterinary journal, 2008-04, Vol.49 (4), p.393-397 |
| issn | 0008-5286 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | animal pathology Animals atrophy case studies disease course disease diagnosis dog diseases Dog Diseases - diagnosis Dog Diseases - genetics Dogs Fatal Outcome genetic disorders histopathology Labrador Retriever leg weakness Male males microstructure mitochondria Muscle Weakness - etiology Muscle Weakness - veterinary muscles Muscular Atrophy - diagnosis Muscular Atrophy - genetics Muscular Atrophy - veterinary Muscular Diseases - diagnosis Muscular Diseases - genetics Muscular Diseases - veterinary puppies Scientific signs and symptoms (animals and humans) |
| title | possible new inherited myopathy in a young Labrador retriever |
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