Serum Cardiac Markers in Patients with Acute Myocardial Infarction: Oxidative Stress, C-Reactive Protein and N-Terminal Probrain Natriuretic Peptide

Serum Cardiac Markers in Patients with Acute Myocardial Infarction: Oxidative Stress, C-Reactive Protein and N-Terminal Probrain Natriuretic Peptide

The aim of this study was to investigate the predictive value of an oxidative stress, C-reactive protein (CRP) and N-terminal probrain natriuretic peptide (NT-proBNP) biomarkers in acute myocardial infarction (AMI). The study population contained 100 patients with AMI and 40 healthy subjects. Malond...

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Veröffentlicht in:Journal of Clinical Biochemistry and Nutrition 2007, Vol.41(1), pp.50-57
Hauptverfasser: Kasap, Seçil, Gönenç, Aymelek, Şener, Derya Erten, Hisar, İsmet
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acute myocardial infarction
C-reactive protein
N-terminal probrain natriuretic peptide
Original
oxidative stress
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container_title Journal of Clinical Biochemistry and Nutrition
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creator Kasap, Seçil
Gönenç, Aymelek
Şener, Derya Erten
Hisar, İsmet
description The aim of this study was to investigate the predictive value of an oxidative stress, C-reactive protein (CRP) and N-terminal probrain natriuretic peptide (NT-proBNP) biomarkers in acute myocardial infarction (AMI). The study population contained 100 patients with AMI and 40 healthy subjects. Malondialdehyde (MDA) was measured as thiobarbituric acid reactive substances. Total antioxidant status (TAC) was assayed with colorimetric method. CRP and NT-proBNP was quantitated by immunoassay. MDA, CRP and NT-proBNP levels were found significantly high in patients with AMI as compared to healthy controls (p
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The study population contained 100 patients with AMI and 40 healthy subjects. Malondialdehyde (MDA) was measured as thiobarbituric acid reactive substances. Total antioxidant status (TAC) was assayed with colorimetric method. CRP and NT-proBNP was quantitated by immunoassay. MDA, CRP and NT-proBNP levels were found significantly high in patients with AMI as compared to healthy controls (p&lt;0.01). Patients were divided into six groups based on the presence of disease history before AMI. In patients with non-disease before AMI. MDA, CRP and NT-proBNP levels were lowest among the patient groups. MDA levels in patients with hyperlipidemia/ diabetes/renal disease were higher than the other groups. TAC levels in patients with hypertension were lower than as compared to healthy controls (p&lt;0.05). CRP levels in hypertension + hyperlipidemia patients and NT-proBNP levels in cardiovascular + hypertension patients were found high as compared to other patient groups. 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Clin. Biochem. Nutr.</addtitle><description>The aim of this study was to investigate the predictive value of an oxidative stress, C-reactive protein (CRP) and N-terminal probrain natriuretic peptide (NT-proBNP) biomarkers in acute myocardial infarction (AMI). The study population contained 100 patients with AMI and 40 healthy subjects. Malondialdehyde (MDA) was measured as thiobarbituric acid reactive substances. Total antioxidant status (TAC) was assayed with colorimetric method. CRP and NT-proBNP was quantitated by immunoassay. MDA, CRP and NT-proBNP levels were found significantly high in patients with AMI as compared to healthy controls (p&lt;0.01). Patients were divided into six groups based on the presence of disease history before AMI. In patients with non-disease before AMI. MDA, CRP and NT-proBNP levels were lowest among the patient groups. MDA levels in patients with hyperlipidemia/ diabetes/renal disease were higher than the other groups. TAC levels in patients with hypertension were lower than as compared to healthy controls (p&lt;0.05). CRP levels in hypertension + hyperlipidemia patients and NT-proBNP levels in cardiovascular + hypertension patients were found high as compared to other patient groups. It is concluded that serum levels of MDA, CRP and NT-proBNP were significantly increased in patients with AMI and these markers were strongly predictive in AMI.</description><subject>acute myocardial infarction</subject><subject>C-reactive protein</subject><subject>N-terminal probrain natriuretic peptide</subject><subject>Original</subject><subject>oxidative stress</subject><issn>0912-0009</issn><issn>1880-5086</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNpVkUtv1DAUhS0EokNhxxp5x6YpdhwnMQuqasSjUh8jWtbWjXPT8ZA4g-0U-j_4wbjNaADJupbO_Xzs60PIa86OBS-LdxvTuOOcsSqtJ2TB65plktXlU7JgiucZY0wdkBchbBgrSlkWz8kBr4XKOeML8vsa_TTQJfjWgqEX4L-jD9Q6uoJo0cVAf9q4pqdmikgv7kfzSPb0zHXgTbSje0-vftk20XdIr6PHEI7oMvuKYB6llR8jJj9wLb3MbtAP1qXzSW48JP0SoreTx2gNXeE22hZfkmcd9AFf7fZD8u3Tx5vll-z86vPZ8vQ8MzJXMatAibrDiishajCyhaoRhWqMlHkhKzSqKfOkCIaMoaorIQRvoBFdxaHOjTgkH2bf7dQM2Jo0rodeb70dwN_rEaz-v-PsWt-OdzrPq0LVKhm83Rn48ceEIerBBoN9Dw7HKehKFImUkiXyaCaNH0Pw2O1v4Uw_5KgfctS7HBP-5t-X_YV3wSXgZAY2IcIt7gHw6R97nN0KrvlcJNt3zBq8Rif-AHC4syk</recordid><startdate>20070701</startdate><enddate>20070701</enddate><creator>Kasap, Seçil</creator><creator>Gönenç, Aymelek</creator><creator>Şener, Derya Erten</creator><creator>Hisar, İsmet</creator><general>SOCIETY FOR FREE RADICAL RESEARCH JAPAN</general><general>the Society for Free Radical Research Japan</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20070701</creationdate><title>Serum Cardiac Markers in Patients with Acute Myocardial Infarction: Oxidative Stress, C-Reactive Protein and N-Terminal Probrain Natriuretic Peptide</title><author>Kasap, Seçil ; Gönenç, Aymelek ; Şener, Derya Erten ; Hisar, İsmet</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c529t-7a938fe719338ac5da7b349bc552457ec9b62b3430e00e9873331bab3f71a82c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>acute myocardial infarction</topic><topic>C-reactive protein</topic><topic>N-terminal probrain natriuretic peptide</topic><topic>Original</topic><topic>oxidative stress</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kasap, Seçil</creatorcontrib><creatorcontrib>Gönenç, Aymelek</creatorcontrib><creatorcontrib>Şener, Derya Erten</creatorcontrib><creatorcontrib>Hisar, İsmet</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Clinical Biochemistry and Nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kasap, Seçil</au><au>Gönenç, Aymelek</au><au>Şener, Derya Erten</au><au>Hisar, İsmet</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum Cardiac Markers in Patients with Acute Myocardial Infarction: Oxidative Stress, C-Reactive Protein and N-Terminal Probrain Natriuretic Peptide</atitle><jtitle>Journal of Clinical Biochemistry and Nutrition</jtitle><addtitle>J. Clin. Biochem. Nutr.</addtitle><date>2007-07-01</date><risdate>2007</risdate><volume>41</volume><issue>1</issue><spage>50</spage><epage>57</epage><pages>50-57</pages><issn>0912-0009</issn><eissn>1880-5086</eissn><abstract>The aim of this study was to investigate the predictive value of an oxidative stress, C-reactive protein (CRP) and N-terminal probrain natriuretic peptide (NT-proBNP) biomarkers in acute myocardial infarction (AMI). The study population contained 100 patients with AMI and 40 healthy subjects. Malondialdehyde (MDA) was measured as thiobarbituric acid reactive substances. Total antioxidant status (TAC) was assayed with colorimetric method. CRP and NT-proBNP was quantitated by immunoassay. MDA, CRP and NT-proBNP levels were found significantly high in patients with AMI as compared to healthy controls (p&lt;0.01). Patients were divided into six groups based on the presence of disease history before AMI. In patients with non-disease before AMI. 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subjects acute myocardial infarction
C-reactive protein
N-terminal probrain natriuretic peptide
Original
oxidative stress
title Serum Cardiac Markers in Patients with Acute Myocardial Infarction: Oxidative Stress, C-Reactive Protein and N-Terminal Probrain Natriuretic Peptide
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