Pneumococcal meningitis in the North East Thames Region UK: epidemiology and molecular analysis of isolates
One hundred and fourteen cases of pneumococcal meningitis were identified by prospective laboratory based surveillance during 1990–3 in the North East Thames Region. Higher rates of disease were seen in Asians (2·1/100 000) than Caucasians (0·8/100 000) (P = 0·002). The incidence of meningitis was h...
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| Veröffentlicht in: | Epidemiology and infection 1996-08, Vol.117 (1), p.95-102 |
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| creator | Urwin, G. Yuan, M. F. Hall, L. M. C. Brown, K. Efstratiou, A. Feldman, R. A. |
| description | One hundred and fourteen cases of pneumococcal meningitis were identified by prospective laboratory based surveillance during 1990–3 in the North East Thames Region. Higher rates of disease were seen in Asians (2·1/100 000) than Caucasians (0·8/100 000) (P = 0·002). The incidence of meningitis was higher in children than adults, while mortality rates were highest in adults over the age of 60 (48%). In 72 cases, both blood and CSF were culture positive. Serotyping of 65 isolates collected identified 22 serotypes (and one non-typable) causing disease, the most common being serotype 6 (13 cases) and serotype 14 (11 cases). Overall, 90% of serotype antigens identified were represented in the 23 valent vaccine. Ribotyping of 62 isolates identified 35 different patterns, of which 26 were single types. Different ribotypes were found among isolates of the same serotypes, with the exception of serotype 14, where 9 of 11 isolates had the same ribotype pattern. Four percent of isolates had reduced susceptibility to penicillin, but no high level penicillin resistance was found. |
| doi_str_mv | 10.1017/S0950268800001175 |
| format | Article |
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F. ; Hall, L. M. C. ; Brown, K. ; Efstratiou, A. ; Feldman, R. A.</creator><creatorcontrib>Urwin, G. ; Yuan, M. F. ; Hall, L. M. C. ; Brown, K. ; Efstratiou, A. ; Feldman, R. A.</creatorcontrib><description>One hundred and fourteen cases of pneumococcal meningitis were identified by prospective laboratory based surveillance during 1990–3 in the North East Thames Region. Higher rates of disease were seen in Asians (2·1/100 000) than Caucasians (0·8/100 000) (P = 0·002). The incidence of meningitis was higher in children than adults, while mortality rates were highest in adults over the age of 60 (48%). In 72 cases, both blood and CSF were culture positive. Serotyping of 65 isolates collected identified 22 serotypes (and one non-typable) causing disease, the most common being serotype 6 (13 cases) and serotype 14 (11 cases). Overall, 90% of serotype antigens identified were represented in the 23 valent vaccine. Ribotyping of 62 isolates identified 35 different patterns, of which 26 were single types. Different ribotypes were found among isolates of the same serotypes, with the exception of serotype 14, where 9 of 11 isolates had the same ribotype pattern. Four percent of isolates had reduced susceptibility to penicillin, but no high level penicillin resistance was found.</description><identifier>ISSN: 0950-2688</identifier><identifier>EISSN: 1469-4409</identifier><identifier>DOI: 10.1017/S0950268800001175</identifier><identifier>PMID: 8760955</identifier><identifier>CODEN: EPINEU</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Adolescent ; Adult ; Antigens ; Antigens, Bacterial - cerebrospinal fluid ; Bacterial diseases ; Bacteriology ; Biological and medical sciences ; Blood ; Child ; Child, Preschool ; Children ; England - epidemiology ; England - ethnology ; Epidemiology ; Female ; Fundamental and applied biological sciences. Psychology ; Human bacterial diseases ; Humans ; Infant ; Infectious diseases ; Male ; Medical sciences ; Meningitis, Pneumococcal - epidemiology ; Meningitis, Pneumococcal - ethnology ; Meningitis, Pneumococcal - microbiology ; Microbial Sensitivity Tests ; Microbiology ; Middle Aged ; Penicillin ; Pneumococcal meningitis ; Prospective Studies ; Ribotyping ; Serotyping ; Staphylococcal infections, streptococcal infections, pneumococcal infections ; Streptococcus pneumoniae ; Streptococcus pneumoniae - classification ; Streptococcus pneumoniae - immunology ; Streptococcus pneumoniae - isolation & purification ; Vaccination</subject><ispartof>Epidemiology and infection, 1996-08, Vol.117 (1), p.95-102</ispartof><rights>Copyright © Cambridge University Press 1996</rights><rights>Copyright 1996 Cambridge University Press</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4725-e82c812e2dfc90994655169448b1bead23161ba54099dcb2298d46aa0347dadd3</citedby><cites>FETCH-LOGICAL-c4725-e82c812e2dfc90994655169448b1bead23161ba54099dcb2298d46aa0347dadd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3864636$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3864636$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,885,27924,27925,53791,53793,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3182275$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8760955$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Urwin, G.</creatorcontrib><creatorcontrib>Yuan, M. F.</creatorcontrib><creatorcontrib>Hall, L. M. C.</creatorcontrib><creatorcontrib>Brown, K.</creatorcontrib><creatorcontrib>Efstratiou, A.</creatorcontrib><creatorcontrib>Feldman, R. A.</creatorcontrib><title>Pneumococcal meningitis in the North East Thames Region UK: epidemiology and molecular analysis of isolates</title><title>Epidemiology and infection</title><addtitle>Epidemiol. Infect</addtitle><description>One hundred and fourteen cases of pneumococcal meningitis were identified by prospective laboratory based surveillance during 1990–3 in the North East Thames Region. Higher rates of disease were seen in Asians (2·1/100 000) than Caucasians (0·8/100 000) (P = 0·002). The incidence of meningitis was higher in children than adults, while mortality rates were highest in adults over the age of 60 (48%). In 72 cases, both blood and CSF were culture positive. Serotyping of 65 isolates collected identified 22 serotypes (and one non-typable) causing disease, the most common being serotype 6 (13 cases) and serotype 14 (11 cases). Overall, 90% of serotype antigens identified were represented in the 23 valent vaccine. Ribotyping of 62 isolates identified 35 different patterns, of which 26 were single types. Different ribotypes were found among isolates of the same serotypes, with the exception of serotype 14, where 9 of 11 isolates had the same ribotype pattern. Four percent of isolates had reduced susceptibility to penicillin, but no high level penicillin resistance was found.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Antigens</subject><subject>Antigens, Bacterial - cerebrospinal fluid</subject><subject>Bacterial diseases</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>England - epidemiology</subject><subject>England - ethnology</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infant</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Meningitis, Pneumococcal - epidemiology</subject><subject>Meningitis, Pneumococcal - ethnology</subject><subject>Meningitis, Pneumococcal - microbiology</subject><subject>Microbial Sensitivity Tests</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>Penicillin</subject><subject>Pneumococcal meningitis</subject><subject>Prospective Studies</subject><subject>Ribotyping</subject><subject>Serotyping</subject><subject>Staphylococcal infections, streptococcal infections, pneumococcal infections</subject><subject>Streptococcus pneumoniae</subject><subject>Streptococcus pneumoniae - classification</subject><subject>Streptococcus pneumoniae - immunology</subject><subject>Streptococcus pneumoniae - isolation & purification</subject><subject>Vaccination</subject><issn>0950-2688</issn><issn>1469-4409</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV-L1DAUxYso67j6AQSFPIhv1SZt0sSHBVnX1XX9v_scbpPbTmbbZkxacb69GWYYFUHzEsLv3EPOPVn2kBbPaEHr518LxQsmpCzSobTmt7IFrYTKq6pQt7PFFudbfje7F-MqiRST9VF2JGuRGF9kN59GnAdvvDHQkwFHN3ZucpG4kUxLJB98mJbkDOJErpYwYCRfsHN-JNfvXhBcO4uD873vNgRGSwbfo5l7COkF_SYmH98SF30PE8b72Z0W-ogP9vdxdv367Or0TX758fzt6cvL3FQ14zlKZiRlyGxrVKFUJTinQlWVbGiDYFlJBW2Ap4jKmoYxJW0lAIqyqi1YWx5nJzvf9dwMaA2OU4Ber4MbIGy0B6f_JKNb6s5_14zVVEieDJ7uDYL_NmOc9OCiwb6HEf0cdS1ZWjIr_iukXCiVlp6EdCc0wccYsD38hhZ6W6X-q8o08_j3GIeJfXeJP9lziKm8NsBoXDzISipTnq3s0U62ipMPv7AUlShFwvkOuzjhjwOGcKNFXdZci_PP-j1Tr_gFvdBbfblPAkMTnO1Qr_wcUt3xH1l-Am-2zrY</recordid><startdate>19960801</startdate><enddate>19960801</enddate><creator>Urwin, G.</creator><creator>Yuan, M. F.</creator><creator>Hall, L. M. C.</creator><creator>Brown, K.</creator><creator>Efstratiou, A.</creator><creator>Feldman, R. A.</creator><general>Cambridge University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19960801</creationdate><title>Pneumococcal meningitis in the North East Thames Region UK: epidemiology and molecular analysis of isolates</title><author>Urwin, G. ; Yuan, M. F. ; Hall, L. M. C. ; Brown, K. ; Efstratiou, A. ; Feldman, R. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4725-e82c812e2dfc90994655169448b1bead23161ba54099dcb2298d46aa0347dadd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Antigens</topic><topic>Antigens, Bacterial - cerebrospinal fluid</topic><topic>Bacterial diseases</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Blood</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>England - epidemiology</topic><topic>England - ethnology</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infant</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Meningitis, Pneumococcal - epidemiology</topic><topic>Meningitis, Pneumococcal - ethnology</topic><topic>Meningitis, Pneumococcal - microbiology</topic><topic>Microbial Sensitivity Tests</topic><topic>Microbiology</topic><topic>Middle Aged</topic><topic>Penicillin</topic><topic>Pneumococcal meningitis</topic><topic>Prospective Studies</topic><topic>Ribotyping</topic><topic>Serotyping</topic><topic>Staphylococcal infections, streptococcal infections, pneumococcal infections</topic><topic>Streptococcus pneumoniae</topic><topic>Streptococcus pneumoniae - classification</topic><topic>Streptococcus pneumoniae - immunology</topic><topic>Streptococcus pneumoniae - isolation & purification</topic><topic>Vaccination</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Urwin, G.</creatorcontrib><creatorcontrib>Yuan, M. F.</creatorcontrib><creatorcontrib>Hall, L. M. C.</creatorcontrib><creatorcontrib>Brown, K.</creatorcontrib><creatorcontrib>Efstratiou, A.</creatorcontrib><creatorcontrib>Feldman, R. A.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Epidemiology and infection</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Urwin, G.</au><au>Yuan, M. F.</au><au>Hall, L. M. C.</au><au>Brown, K.</au><au>Efstratiou, A.</au><au>Feldman, R. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pneumococcal meningitis in the North East Thames Region UK: epidemiology and molecular analysis of isolates</atitle><jtitle>Epidemiology and infection</jtitle><addtitle>Epidemiol. Infect</addtitle><date>1996-08-01</date><risdate>1996</risdate><volume>117</volume><issue>1</issue><spage>95</spage><epage>102</epage><pages>95-102</pages><issn>0950-2688</issn><eissn>1469-4409</eissn><coden>EPINEU</coden><abstract>One hundred and fourteen cases of pneumococcal meningitis were identified by prospective laboratory based surveillance during 1990–3 in the North East Thames Region. Higher rates of disease were seen in Asians (2·1/100 000) than Caucasians (0·8/100 000) (P = 0·002). The incidence of meningitis was higher in children than adults, while mortality rates were highest in adults over the age of 60 (48%). In 72 cases, both blood and CSF were culture positive. Serotyping of 65 isolates collected identified 22 serotypes (and one non-typable) causing disease, the most common being serotype 6 (13 cases) and serotype 14 (11 cases). Overall, 90% of serotype antigens identified were represented in the 23 valent vaccine. Ribotyping of 62 isolates identified 35 different patterns, of which 26 were single types. Different ribotypes were found among isolates of the same serotypes, with the exception of serotype 14, where 9 of 11 isolates had the same ribotype pattern. Four percent of isolates had reduced susceptibility to penicillin, but no high level penicillin resistance was found.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>8760955</pmid><doi>10.1017/S0950268800001175</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0950-2688 |
| ispartof | Epidemiology and infection, 1996-08, Vol.117 (1), p.95-102 |
| issn | 0950-2688 1469-4409 |
| language | eng |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; PubMed Central |
| subjects | Adolescent Adult Antigens Antigens, Bacterial - cerebrospinal fluid Bacterial diseases Bacteriology Biological and medical sciences Blood Child Child, Preschool Children England - epidemiology England - ethnology Epidemiology Female Fundamental and applied biological sciences. Psychology Human bacterial diseases Humans Infant Infectious diseases Male Medical sciences Meningitis, Pneumococcal - epidemiology Meningitis, Pneumococcal - ethnology Meningitis, Pneumococcal - microbiology Microbial Sensitivity Tests Microbiology Middle Aged Penicillin Pneumococcal meningitis Prospective Studies Ribotyping Serotyping Staphylococcal infections, streptococcal infections, pneumococcal infections Streptococcus pneumoniae Streptococcus pneumoniae - classification Streptococcus pneumoniae - immunology Streptococcus pneumoniae - isolation & purification Vaccination |
| title | Pneumococcal meningitis in the North East Thames Region UK: epidemiology and molecular analysis of isolates |
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