Epidemiology of invasive Haemophilus influenzae infections in England and Wales in the pre-vaccination era (1990–2)
This survey defined the pattern of invasive Haemophilus influenzae infections during 1990–2 in six regions in England and Wales during the pre-vaccination era providing a baseline against which any changes in patterns of disease due to the introduction of the Haemophilus influenzae type b vaccinatio...
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| Veröffentlicht in: | Epidemiology and infection 1995-08, Vol.115 (1), p.89-100 |
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| creator | Anderson, E. C. Begg, N. T. Crawshaw, S. C. Hargreaves, R. M. Howard, A. J. Slack, M. P. E. |
| description | This survey defined the pattern of invasive Haemophilus influenzae infections during 1990–2 in six regions in England and Wales during the pre-vaccination era providing a baseline against which any changes in patterns of disease due to the introduction of the Haemophilus influenzae type b vaccination programme can be monitored. A total of 946 cases of invasive Haemophilus influenzae were recorded during the survey period of which almost 90 % were due to type b and most of the remainder were non-typeable. Type b infections occurred predominantly in children less than 5 years of age (88%) with the highest attack rate in male infants in the 6–11 month age group. Diagnostic category varied with both age and serotype; meningitis was the commonest presentation overall but pneumonia and bacteraemia were more common in adults and non-typeable isolates. Mortality was highest in neonates and the elderly (over 65 years of age) who were more likely to have an underlying predisposing condition than older children and adults. Children under 5 years of age had a higher case fatality rate for non-typeable than for type b infections. Ampicillin resistance was 15% and there were no cefotaxime resistant type b isolates. |
| doi_str_mv | 10.1017/S0950268800058155 |
| format | Article |
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C. ; Begg, N. T. ; Crawshaw, S. C. ; Hargreaves, R. M. ; Howard, A. J. ; Slack, M. P. E.</creator><creatorcontrib>Anderson, E. C. ; Begg, N. T. ; Crawshaw, S. C. ; Hargreaves, R. M. ; Howard, A. J. ; Slack, M. P. E.</creatorcontrib><description>This survey defined the pattern of invasive Haemophilus influenzae infections during 1990–2 in six regions in England and Wales during the pre-vaccination era providing a baseline against which any changes in patterns of disease due to the introduction of the Haemophilus influenzae type b vaccination programme can be monitored. A total of 946 cases of invasive Haemophilus influenzae were recorded during the survey period of which almost 90 % were due to type b and most of the remainder were non-typeable. Type b infections occurred predominantly in children less than 5 years of age (88%) with the highest attack rate in male infants in the 6–11 month age group. Diagnostic category varied with both age and serotype; meningitis was the commonest presentation overall but pneumonia and bacteraemia were more common in adults and non-typeable isolates. Mortality was highest in neonates and the elderly (over 65 years of age) who were more likely to have an underlying predisposing condition than older children and adults. Children under 5 years of age had a higher case fatality rate for non-typeable than for type b infections. Ampicillin resistance was 15% and there were no cefotaxime resistant type b isolates.</description><identifier>ISSN: 0950-2688</identifier><identifier>EISSN: 1469-4409</identifier><identifier>DOI: 10.1017/S0950268800058155</identifier><identifier>PMID: 7641841</identifier><identifier>CODEN: EPINEU</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Adolescent ; Adult ; Age Factors ; Aged ; Bacterial diseases ; Bacterial diseases of the respiratory system ; Biological and medical sciences ; Child ; Child, Preschool ; Drug Resistance, Microbial ; Epidemiologic Methods ; Female ; Haemophilus Infections - epidemiology ; Haemophilus Infections - microbiology ; Haemophilus Infections - mortality ; Haemophilus influenzae - classification ; Haemophilus influenzae - immunology ; Haemophilus influenzae - isolation & purification ; Human bacterial diseases ; Humans ; Infant ; Infectious diseases ; Male ; Medical sciences ; Middle Aged ; Sex Factors ; Surveys and Questionnaires ; United Kingdom - epidemiology ; Vaccination</subject><ispartof>Epidemiology and infection, 1995-08, Vol.115 (1), p.89-100</ispartof><rights>Copyright © Cambridge University Press 1995</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-67bfcb42914884fd3bb46717a52137bcad1fd55751b56659364ee81a12a1417f3</citedby><cites>FETCH-LOGICAL-c431t-67bfcb42914884fd3bb46717a52137bcad1fd55751b56659364ee81a12a1417f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2271549/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2271549/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,725,778,782,883,27911,27912,53778,53780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3628626$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7641841$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Anderson, E. C.</creatorcontrib><creatorcontrib>Begg, N. T.</creatorcontrib><creatorcontrib>Crawshaw, S. C.</creatorcontrib><creatorcontrib>Hargreaves, R. M.</creatorcontrib><creatorcontrib>Howard, A. J.</creatorcontrib><creatorcontrib>Slack, M. P. E.</creatorcontrib><title>Epidemiology of invasive Haemophilus influenzae infections in England and Wales in the pre-vaccination era (1990–2)</title><title>Epidemiology and infection</title><addtitle>Epidemiol. Infect</addtitle><description>This survey defined the pattern of invasive Haemophilus influenzae infections during 1990–2 in six regions in England and Wales during the pre-vaccination era providing a baseline against which any changes in patterns of disease due to the introduction of the Haemophilus influenzae type b vaccination programme can be monitored. A total of 946 cases of invasive Haemophilus influenzae were recorded during the survey period of which almost 90 % were due to type b and most of the remainder were non-typeable. Type b infections occurred predominantly in children less than 5 years of age (88%) with the highest attack rate in male infants in the 6–11 month age group. Diagnostic category varied with both age and serotype; meningitis was the commonest presentation overall but pneumonia and bacteraemia were more common in adults and non-typeable isolates. Mortality was highest in neonates and the elderly (over 65 years of age) who were more likely to have an underlying predisposing condition than older children and adults. Children under 5 years of age had a higher case fatality rate for non-typeable than for type b infections. Ampicillin resistance was 15% and there were no cefotaxime resistant type b isolates.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Bacterial diseases</subject><subject>Bacterial diseases of the respiratory system</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Drug Resistance, Microbial</subject><subject>Epidemiologic Methods</subject><subject>Female</subject><subject>Haemophilus Infections - epidemiology</subject><subject>Haemophilus Infections - microbiology</subject><subject>Haemophilus Infections - mortality</subject><subject>Haemophilus influenzae - classification</subject><subject>Haemophilus influenzae - immunology</subject><subject>Haemophilus influenzae - isolation & purification</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infant</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Sex Factors</subject><subject>Surveys and Questionnaires</subject><subject>United Kingdom - epidemiology</subject><subject>Vaccination</subject><issn>0950-2688</issn><issn>1469-4409</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc9u1DAQxi0EKkvhATgg5cABDgGP478XpKpaWsQCqgriaE0SZ9cl60R2sqKceAfekCchYVcrEBIHy9b3--bzaIaQx0BfAAX18poaQZnUmlIqNAhxhyyAS5NzTs1dsphxPvP75EFKN5PLMK1OyImSHDSHBRmXva_d1ndtt77NuibzYYfJ71x2iW7b9RvfjmkSm3Z04Ru6-emqwXdhVrNlWLcY6mw-n7F1v8Vh47I-unyHVeUDzubMRcyegTH05_cf7PlDcq_BNrlHh_uUfHq9_Hh-ma8-XLw5P1vlFS9gyKUqm6rkzADXmjd1UZZcKlAoGBSqrLCGphZCCSiFlMIUkjunAYEhcFBNcUpe7XP7sdy6unJhiNjaPvotxlvbobd_k-A3dt3tLGMKBDdTAOwDqtilFF1zrAVq5xXYf1Yw1Tz589NjxWHmE3964JgqbJuIofLpaCsk05LJyZbvbT4N7usRY_xipSqUsPLiypp37-W1vlrZt5O_OLSK2zL6eu3sTTfGMM33P83-An9Xrls</recordid><startdate>19950801</startdate><enddate>19950801</enddate><creator>Anderson, E. C.</creator><creator>Begg, N. T.</creator><creator>Crawshaw, S. C.</creator><creator>Hargreaves, R. M.</creator><creator>Howard, A. J.</creator><creator>Slack, M. P. E.</creator><general>Cambridge University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>19950801</creationdate><title>Epidemiology of invasive Haemophilus influenzae infections in England and Wales in the pre-vaccination era (1990–2)</title><author>Anderson, E. C. ; Begg, N. T. ; Crawshaw, S. C. ; Hargreaves, R. M. ; Howard, A. J. ; Slack, M. P. E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-67bfcb42914884fd3bb46717a52137bcad1fd55751b56659364ee81a12a1417f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Bacterial diseases</topic><topic>Bacterial diseases of the respiratory system</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Drug Resistance, Microbial</topic><topic>Epidemiologic Methods</topic><topic>Female</topic><topic>Haemophilus Infections - epidemiology</topic><topic>Haemophilus Infections - microbiology</topic><topic>Haemophilus Infections - mortality</topic><topic>Haemophilus influenzae - classification</topic><topic>Haemophilus influenzae - immunology</topic><topic>Haemophilus influenzae - isolation & purification</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infant</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Sex Factors</topic><topic>Surveys and Questionnaires</topic><topic>United Kingdom - epidemiology</topic><topic>Vaccination</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Anderson, E. C.</creatorcontrib><creatorcontrib>Begg, N. T.</creatorcontrib><creatorcontrib>Crawshaw, S. C.</creatorcontrib><creatorcontrib>Hargreaves, R. M.</creatorcontrib><creatorcontrib>Howard, A. J.</creatorcontrib><creatorcontrib>Slack, M. P. E.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Epidemiology and infection</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Anderson, E. C.</au><au>Begg, N. T.</au><au>Crawshaw, S. C.</au><au>Hargreaves, R. M.</au><au>Howard, A. J.</au><au>Slack, M. P. E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epidemiology of invasive Haemophilus influenzae infections in England and Wales in the pre-vaccination era (1990–2)</atitle><jtitle>Epidemiology and infection</jtitle><addtitle>Epidemiol. Infect</addtitle><date>1995-08-01</date><risdate>1995</risdate><volume>115</volume><issue>1</issue><spage>89</spage><epage>100</epage><pages>89-100</pages><issn>0950-2688</issn><eissn>1469-4409</eissn><coden>EPINEU</coden><abstract>This survey defined the pattern of invasive Haemophilus influenzae infections during 1990–2 in six regions in England and Wales during the pre-vaccination era providing a baseline against which any changes in patterns of disease due to the introduction of the Haemophilus influenzae type b vaccination programme can be monitored. A total of 946 cases of invasive Haemophilus influenzae were recorded during the survey period of which almost 90 % were due to type b and most of the remainder were non-typeable. Type b infections occurred predominantly in children less than 5 years of age (88%) with the highest attack rate in male infants in the 6–11 month age group. Diagnostic category varied with both age and serotype; meningitis was the commonest presentation overall but pneumonia and bacteraemia were more common in adults and non-typeable isolates. Mortality was highest in neonates and the elderly (over 65 years of age) who were more likely to have an underlying predisposing condition than older children and adults. Children under 5 years of age had a higher case fatality rate for non-typeable than for type b infections. Ampicillin resistance was 15% and there were no cefotaxime resistant type b isolates.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>7641841</pmid><doi>10.1017/S0950268800058155</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Epidemiology and infection, 1995-08, Vol.115 (1), p.89-100 |
| issn | 0950-2688 1469-4409 |
| language | eng |
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| source | MEDLINE; Jstor Complete Legacy; PubMed Central |
| subjects | Adolescent Adult Age Factors Aged Bacterial diseases Bacterial diseases of the respiratory system Biological and medical sciences Child Child, Preschool Drug Resistance, Microbial Epidemiologic Methods Female Haemophilus Infections - epidemiology Haemophilus Infections - microbiology Haemophilus Infections - mortality Haemophilus influenzae - classification Haemophilus influenzae - immunology Haemophilus influenzae - isolation & purification Human bacterial diseases Humans Infant Infectious diseases Male Medical sciences Middle Aged Sex Factors Surveys and Questionnaires United Kingdom - epidemiology Vaccination |
| title | Epidemiology of invasive Haemophilus influenzae infections in England and Wales in the pre-vaccination era (1990–2) |
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