Epigenetic analysis of the human α- and β-globin gene clusters

K562 erythroleukemia cells have been widely used as a model for the study of globin gene regulation. A number of agents have been shown to activate or suppress globin gene expression in these cells. However, the molecular effects of these agents on the epigenetic configuration of the α- and γ-globin...

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Veröffentlicht in:	Blood cells, molecules, & diseases molecules, & diseases, 2008-03, Vol.40 (2), p.166-173
Hauptverfasser:	Fathallah, Hassana, Portnoy, Gregory, Atweh, George F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Butyrates - pharmacology Chromatin DNA Methylation Epigenesis, Genetic Erythroid cells Erythroid Precursor Cells - enzymology Erythroid Precursor Cells - metabolism Fetal Hemoglobin - genetics Fetal Hemoglobin - metabolism Gene expression Gene Expression Regulation, Developmental Globins Globins - genetics Globins - metabolism HeLa Cells Hemin - pharmacology Histone acetylation Histone Deacetylases - genetics Histone Deacetylases - metabolism Histones - genetics Histones - metabolism Humans K562 Cells Multigene Family Promoter Regions, Genetic
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