Inhibition of IL‐1β and TNF‐α Secretion from Resting and Activated Human Immunocytes by the Homeopathic Medication Traumeel ® S
Abstract Traumeel ® S (Traumeel), a mixture of highly diluted (10 -1 ‐10 -9 ) extracts from medicinal plants and minerals is widely used in humans to relieve trauma, inflammation and degenerative processes. However, little is known about its possible effects on the behavior of immune cells. The effe...
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| Veröffentlicht in: | Clinical & developmental immunology 2004-06, Vol.11 (2), p.143-149 |
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| container_title | Clinical & developmental immunology |
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| creator | Porozov, Svetlana Cahalon, Liora Weiser, Michael Branski, David Lider, Ofer Oberbaum, Menachem |
| description | Abstract
Traumeel
®
S (Traumeel), a mixture of highly diluted
(10
-1
‐10
-9
) extracts from
medicinal plants and minerals is widely used in humans to relieve trauma, inflammation
and degenerative processes. However, little is known about its possible effects on
the behavior of immune cells. The effects of Traumeel were examined
in vitro
on the ability
of resting and PHA‐, PMA‐ or TNF‐α‐activated human T cells, monocytes, and gut epithelial
cells to secrete the prototypic pro‐inflammatory
mediators IL‐1β, TNF‐α and IL‐8 over a period
of 24‐72 h. Traumeel inhibited the secretion of all three agents in resting, as well as
activated
immune cells. IL‐β secretion was reduced by up to 70% in both resting and activated cells;
TNF‐α secretion was reduced by up to 65 and 54%, respectively,
and IL‐8 secretion was
reduced by 50% in both resting and activated cells (P |
| doi_str_mv | 10.1080/10446670410001722203 |
| format | Article |
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Traumeel
®
S (Traumeel), a mixture of highly diluted
(10
-1
‐10
-9
) extracts from
medicinal plants and minerals is widely used in humans to relieve trauma, inflammation
and degenerative processes. However, little is known about its possible effects on
the behavior of immune cells. The effects of Traumeel were examined
in vitro
on the ability
of resting and PHA‐, PMA‐ or TNF‐α‐activated human T cells, monocytes, and gut epithelial
cells to secrete the prototypic pro‐inflammatory
mediators IL‐1β, TNF‐α and IL‐8 over a period
of 24‐72 h. Traumeel inhibited the secretion of all three agents in resting, as well as
activated
immune cells. IL‐β secretion was reduced by up to 70% in both resting and activated cells;
TNF‐α secretion was reduced by up to 65 and 54%, respectively,
and IL‐8 secretion was
reduced by 50% in both resting and activated cells (P<0.01 for all cells). Interestingly,
the effect appeared to be inversely dose‐related; maximal inhibition (usually 30‐60%
inhibition; P<0.01) was seen with dilutions of
10
-3
‐10
-6
of the Traumeel stock material. This
finding suggests that Traumeel does not inhibit immune cells functions by exerting a toxic
effect. Indeed, Traumeel did not affect T cell and monocyte proliferation. Although
additional studies are needed to clarify the mode of action of Traumeel and to demonstrate
causative relationship between the inhibition of cytokine/chemokine secretion in cell culture
and the reported clinical effects of the preparation, our
in vitro
results offer a mechanism for
the anti‐inflammatory effects of Traumeel observed in clinical use.</description><identifier>ISSN: 2314-8861</identifier><identifier>ISSN: 1740-2522</identifier><identifier>EISSN: 2314-7156</identifier><identifier>EISSN: 1740-2530</identifier><identifier>DOI: 10.1080/10446670410001722203</identifier><identifier>PMID: 15330450</identifier><language>eng</language><publisher>Hindawi Publishing Corporation</publisher><ispartof>Clinical & developmental immunology, 2004-06, Vol.11 (2), p.143-149</ispartof><rights>Copyright © 2004 Hindawi Publishing Corporation. 2004 Hindawi Publishing Corporation</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2653-575f512a22b6d60c64a8eb8bb15dd0e2de89ad4c3ac4f91ed996796efcb7ec2d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2270708/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2270708/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids></links><search><creatorcontrib>Porozov, Svetlana</creatorcontrib><creatorcontrib>Cahalon, Liora</creatorcontrib><creatorcontrib>Weiser, Michael</creatorcontrib><creatorcontrib>Branski, David</creatorcontrib><creatorcontrib>Lider, Ofer</creatorcontrib><creatorcontrib>Oberbaum, Menachem</creatorcontrib><title>Inhibition of IL‐1β and TNF‐α Secretion from Resting and Activated Human Immunocytes by the Homeopathic Medication Traumeel ® S</title><title>Clinical & developmental immunology</title><description>Abstract
Traumeel
®
S (Traumeel), a mixture of highly diluted
(10
-1
‐10
-9
) extracts from
medicinal plants and minerals is widely used in humans to relieve trauma, inflammation
and degenerative processes. However, little is known about its possible effects on
the behavior of immune cells. The effects of Traumeel were examined
in vitro
on the ability
of resting and PHA‐, PMA‐ or TNF‐α‐activated human T cells, monocytes, and gut epithelial
cells to secrete the prototypic pro‐inflammatory
mediators IL‐1β, TNF‐α and IL‐8 over a period
of 24‐72 h. Traumeel inhibited the secretion of all three agents in resting, as well as
activated
immune cells. IL‐β secretion was reduced by up to 70% in both resting and activated cells;
TNF‐α secretion was reduced by up to 65 and 54%, respectively,
and IL‐8 secretion was
reduced by 50% in both resting and activated cells (P<0.01 for all cells). Interestingly,
the effect appeared to be inversely dose‐related; maximal inhibition (usually 30‐60%
inhibition; P<0.01) was seen with dilutions of
10
-3
‐10
-6
of the Traumeel stock material. This
finding suggests that Traumeel does not inhibit immune cells functions by exerting a toxic
effect. Indeed, Traumeel did not affect T cell and monocyte proliferation. Although
additional studies are needed to clarify the mode of action of Traumeel and to demonstrate
causative relationship between the inhibition of cytokine/chemokine secretion in cell culture
and the reported clinical effects of the preparation, our
in vitro
results offer a mechanism for
the anti‐inflammatory effects of Traumeel observed in clinical use.</description><issn>2314-8861</issn><issn>1740-2522</issn><issn>2314-7156</issn><issn>1740-2530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNptkU1KA0EUhBtRVGJu4KIvEH39P7MRRNQEooLG9dA_b0xDZjrMTITsXLn2JIIewQN4CE-iJiIIrl49qurbFCH7DA4YZHDIQEqtDUgGAMxwzkFskF0umBwYpvTmj84yzXZIv22jAwVGCJ3pbbLDlBAgFeySx1E9jS52MdU0lXQ0_nh4Yu-v1NaBTi7Pvr73F3qDvsFVpGxSRa-x7WJ9t8oc-y7e2w4DHS4qW9NRVS3q5JcdttQtaTdFOkwVprntptHTCwzR2xVq0thFhTijb8_0Zo9slXbWYv_n9sjt2enkZDgYX52PTo7HA8-1EgNlVKkYt5w7HTR4LW2GLnOOqRAAecAst0F6Yb0sc4Yhz7XJNZbeGfQ8iB45WnPnC1dh8Fh3jZ0V8yZWtlkWycbir1PHaXGX7gvODRjIvgByDfBNatsGy98ug-J7muK_acQn1v-GFA</recordid><startdate>200406</startdate><enddate>200406</enddate><creator>Porozov, Svetlana</creator><creator>Cahalon, Liora</creator><creator>Weiser, Michael</creator><creator>Branski, David</creator><creator>Lider, Ofer</creator><creator>Oberbaum, Menachem</creator><general>Hindawi Publishing Corporation</general><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>200406</creationdate><title>Inhibition of IL‐1β and TNF‐α Secretion from Resting and Activated Human Immunocytes by the Homeopathic Medication Traumeel ® S</title><author>Porozov, Svetlana ; Cahalon, Liora ; Weiser, Michael ; Branski, David ; Lider, Ofer ; Oberbaum, Menachem</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2653-575f512a22b6d60c64a8eb8bb15dd0e2de89ad4c3ac4f91ed996796efcb7ec2d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Porozov, Svetlana</creatorcontrib><creatorcontrib>Cahalon, Liora</creatorcontrib><creatorcontrib>Weiser, Michael</creatorcontrib><creatorcontrib>Branski, David</creatorcontrib><creatorcontrib>Lider, Ofer</creatorcontrib><creatorcontrib>Oberbaum, Menachem</creatorcontrib><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical & developmental immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Porozov, Svetlana</au><au>Cahalon, Liora</au><au>Weiser, Michael</au><au>Branski, David</au><au>Lider, Ofer</au><au>Oberbaum, Menachem</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibition of IL‐1β and TNF‐α Secretion from Resting and Activated Human Immunocytes by the Homeopathic Medication Traumeel ® S</atitle><jtitle>Clinical & developmental immunology</jtitle><date>2004-06</date><risdate>2004</risdate><volume>11</volume><issue>2</issue><spage>143</spage><epage>149</epage><pages>143-149</pages><issn>2314-8861</issn><issn>1740-2522</issn><eissn>2314-7156</eissn><eissn>1740-2530</eissn><abstract>Abstract
Traumeel
®
S (Traumeel), a mixture of highly diluted
(10
-1
‐10
-9
) extracts from
medicinal plants and minerals is widely used in humans to relieve trauma, inflammation
and degenerative processes. However, little is known about its possible effects on
the behavior of immune cells. The effects of Traumeel were examined
in vitro
on the ability
of resting and PHA‐, PMA‐ or TNF‐α‐activated human T cells, monocytes, and gut epithelial
cells to secrete the prototypic pro‐inflammatory
mediators IL‐1β, TNF‐α and IL‐8 over a period
of 24‐72 h. Traumeel inhibited the secretion of all three agents in resting, as well as
activated
immune cells. IL‐β secretion was reduced by up to 70% in both resting and activated cells;
TNF‐α secretion was reduced by up to 65 and 54%, respectively,
and IL‐8 secretion was
reduced by 50% in both resting and activated cells (P<0.01 for all cells). Interestingly,
the effect appeared to be inversely dose‐related; maximal inhibition (usually 30‐60%
inhibition; P<0.01) was seen with dilutions of
10
-3
‐10
-6
of the Traumeel stock material. This
finding suggests that Traumeel does not inhibit immune cells functions by exerting a toxic
effect. Indeed, Traumeel did not affect T cell and monocyte proliferation. Although
additional studies are needed to clarify the mode of action of Traumeel and to demonstrate
causative relationship between the inhibition of cytokine/chemokine secretion in cell culture
and the reported clinical effects of the preparation, our
in vitro
results offer a mechanism for
the anti‐inflammatory effects of Traumeel observed in clinical use.</abstract><pub>Hindawi Publishing Corporation</pub><pmid>15330450</pmid><doi>10.1080/10446670410001722203</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | Wiley Online Library Open Access; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection; PubMed Central Open Access |
| title | Inhibition of IL‐1β and TNF‐α Secretion from Resting and Activated Human Immunocytes by the Homeopathic Medication Traumeel ® S |
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