Regulated Proteolytic Processing of Tie1 Modulates Ligand Responsiveness of the Receptor-tyrosine Kinase Tie2

Regulated ectodomain shedding followed by intramembrane proteolysis has recently been recognized as important in cell signaling and for degradation of several type I transmembrane proteins. The receptor-tyrosine kinase Tie1 is known to undergo ectodomain cleavage generating a membrane-tethered endod...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of biological chemistry 2007-10, Vol.282 (42), p.30509-30517
Hauptverfasser:	Marron, Marie B., Singh, Harprit, Tahir, Tariq A., Kavumkal, Jais, Kim, Hak-Zoo, Koh, Gou Young, Brindle, Nicholas P.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid Precursor Protein Secretases - metabolism Angiopoietin-1 - metabolism Carcinogens - pharmacology Cells, Cultured Endothelial Cells - cytology Endothelial Cells - enzymology Enzyme Activation - drug effects Enzyme Activation - physiology Humans Ligands Phorbol Esters - pharmacology Proteasome Endopeptidase Complex - metabolism Protein Processing, Post-Translational - drug effects Protein Processing, Post-Translational - physiology Receptor, TIE-1 - metabolism Receptor, TIE-2 - metabolism RNA Interference Signal Transduction - drug effects Signal Transduction - physiology Vascular Endothelial Growth Factor A - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!