Reconstitution of protein kinase C-induced contractile Ca2+ sensitization in Triton X-100-demembranated rabbit arterial smooth muscle

Triton X-100-demembranated smooth muscle loses Ca 2+ -sensitizing responsiveness to protein kinase C (PKC) activators while intact and Î±-toxin-permeabilized smooth muscles remain responsive. We attempted to reconstitute the contractile Ca 2+ sensitization by PKC in the demembranated preparations. W...

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Veröffentlicht in:	The Journal of physiology 1999-10, Vol.520 (1), p.139-152
Hauptverfasser:	Kitazawa, T., Takizawa, N., Ikebe, M., Eto, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Calcium - physiology Cell Membrane - drug effects Cell Membrane - physiology Enzyme Activators - pharmacology In Vitro Techniques Isoenzymes - metabolism Isoenzymes - physiology Male Muscle Contraction - drug effects Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - physiology Octoxynol - pharmacology Original Phorbol 12,13-Dibutyrate - pharmacology Phosphorylation Protein Kinase C - metabolism Protein Kinase C - physiology Rabbits Recombinant Proteins - biosynthesis Recombinant Proteins - isolation & purification
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