Brain sites of action of endogenous interleukin-1 in the febrile response to localized inflammation in the rat

Interleukin (IL)-1 is a potent endogenous pyrogen which causes fever when injected into a number of brain sites. However, the brain sites at which endogenous IL-1 acts to influence body temperature remain equivocal. The aim of this study was to determine the effect of local administration of the int...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of physiology 1999-07, Vol.518 (2), p.585-594
Hauptverfasser:	Cartmell, T., Luheshi, G. N., Rothwell, N. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Body Temperature - drug effects Brain - anatomy & histology Brain Chemistry - physiology Dose-Response Relationship, Drug Fever - physiopathology Hypothalamus - anatomy & histology Hypothalamus - drug effects Inflammation - physiopathology Injections, Intraventricular Interleukin-1 - physiology Lipopolysaccharides - pharmacology Male Microinjections Original Rats Rats, Sprague-Dawley Receptors, Interleukin-1 - antagonists & inhibitors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!