Positive and negative inotropic effects of NO donors in atrial and ventricular fibres of the frog heart

The cardiac effects of the NO donors sodium nitroprusside (SNP), S -nitroso- N -acetyl-penicillamine (SNAP) and 3-morpholino-sydnonimine (SIN-1) were studied in frog fibres to evaluate the contribution of cyclic GMP-dependent mechanisms. SNP and SNAP (0Â·1-100 Î¼M) reduced the force of contraction i...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of physiology 1999-07, Vol.518 (2), p.449-461
Hauptverfasser:	Jean-Michel Chesnais, Rodolphe Fischmeister, Pierre-FranÃ§ois MÃ©ry
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoquinolines - pharmacology Animals Cardiology and cardiovascular system Cyclic GMP - metabolism Enzyme Inhibitors - pharmacology Guanylate Cyclase - antagonists & inhibitors Half-Life Heart - drug effects Heart Atria - drug effects Heart Ventricles - drug effects Human health and pathology In Vitro Techniques Life Sciences Molsidomine - analogs & derivatives Molsidomine - pharmacology Muscle Fibers, Skeletal - drug effects Myocardial Contraction - drug effects Nitric Oxide Donors - pharmacology Nitroprusside - pharmacology Original Penicillamine - analogs & derivatives Penicillamine - pharmacology Pharmaceutical sciences Pharmacology Rana esculenta S-Nitroso-N-Acetylpenicillamine
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!