Ocular and systemic bio-distribution of rhodamine-conjugated liposomes loaded with VIP injected into the vitreous of Lewis rats

Local delivery of therapeutic molecules encapsulated within liposomes is a promising method to treat ocular inflammation. The purpose of the present study was to define the biodistribution of rhodamine-conjugated liposomes loaded with vasoactive intestinal peptide (VIP), an immunosuppressive neurope...

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Veröffentlicht in:	Molecular vision 2007-12, Vol.13, p.2263-2274
Hauptverfasser:	Camelo, S, Lajavardi, L, Bochot, A, Goldenberg, B, Naud, M C, Fattal, E, Behar-Cohen, F, de Kozak, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ciliary Body - cytology Ciliary Body - drug effects Ciliary Body - metabolism Conjunctiva - cytology Conjunctiva - drug effects Conjunctiva - metabolism Endocytosis - drug effects Injections Iris - cytology Iris - drug effects Iris - metabolism Liposomes Lymph Nodes - cytology Lymph Nodes - drug effects Lymph Nodes - metabolism Lymphoid Tissue - cytology Lymphoid Tissue - drug effects Lymphoid Tissue - metabolism Male Phagocytes - drug effects Phagocytes - metabolism Phenotype Rats Rats, Inbred Lew Rhodamines - administration & dosage Rhodamines - pharmacokinetics Rhodamines - pharmacology Tissue Distribution - drug effects Vasoactive Intestinal Peptide - administration & dosage Vasoactive Intestinal Peptide - pharmacokinetics Vasoactive Intestinal Peptide - pharmacology Vitreous Body - cytology Vitreous Body - drug effects Vitreous Body - metabolism
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