Molecular epidemiology of clinically significant antibiotic resistance genes
Antimicrobials were first introduced into medical practice a little over 60 years ago and since that time resistant strains of bacteria have arisen in response to the selective pressure of their use. This review uses the paradigm of the evolution and spread of beta‐lactamases and in particular beta‐...
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| Veröffentlicht in: | British journal of pharmacology 2008-03, Vol.153 (S1), p.S406-S413 |
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| description | Antimicrobials were first introduced into medical practice a little over 60 years ago and since that time resistant strains of bacteria have arisen in response to the selective pressure of their use. This review uses the paradigm of the evolution and spread of beta‐lactamases and in particular beta‐lactamases active against antimicrobials used to treat Gram‐negative infections. The emergence and evolution particularly of CTX‐M extended‐spectrum beta‐lactamases (ESBLs) is described together with the molecular mechanisms responsible for both primary mutation and horizontal gene transfer. Reference is also made to other significant antibiotic resistance genes, resistance mechanisms in Gram‐negative bacteria, such as carbepenamases, and plasmid‐mediated fluoroquinolone resistance. The pathogen Staphylococcus aureus is reviewed in detail as an example of a highly successful Gram‐positive bacterial pathogen that has acquired and developed resistance to a wide range of antimicrobials. The role of selective pressures in the environment as well as the medical use of antimicrobials together with the interplay of various genetic mechanisms for horizontal gene transfer are considered in the concluding part of this review.
British Journal of Pharmacology (2008) 153, S406–S413; doi:10.1038/sj.bjp.0707632 |
| doi_str_mv | 10.1038/sj.bjp.0707632 |
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British Journal of Pharmacology (2008) 153, S406–S413; doi:10.1038/sj.bjp.0707632</description><identifier>ISSN: 0007-1188</identifier><identifier>EISSN: 1476-5381</identifier><identifier>DOI: 10.1038/sj.bjp.0707632</identifier><identifier>PMID: 18311156</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animals ; antibiotic resistance ; Bacteria - genetics ; Bacterial Infections - drug therapy ; Bacterial Infections - genetics ; Bacterial Infections - microbiology ; beta‐lactamases ; Drug Resistance, Microbial - genetics ; ESBL ; Genes, Bacterial - physiology ; Humans ; Molecular Epidemiology ; MRSA ; plasmids ; Review ; Staphylococcus aureus</subject><ispartof>British journal of pharmacology, 2008-03, Vol.153 (S1), p.S406-S413</ispartof><rights>2008 British Pharmacological Society</rights><rights>Copyright Nature Publishing Group Mar 2008</rights><rights>Copyright © 2008 Nature Publishing Group 2008 Nature Publishing Group</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5556-79112e6516256fd943adec1cbc9d4a84f91e30003cb40ac043ba0a15b082d9533</citedby><cites>FETCH-LOGICAL-c5556-79112e6516256fd943adec1cbc9d4a84f91e30003cb40ac043ba0a15b082d9533</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268046/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268046/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,1417,1433,27924,27925,45574,45575,46409,46833,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18311156$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hawkey, P M</creatorcontrib><title>Molecular epidemiology of clinically significant antibiotic resistance genes</title><title>British journal of pharmacology</title><addtitle>Br J Pharmacol</addtitle><description>Antimicrobials were first introduced into medical practice a little over 60 years ago and since that time resistant strains of bacteria have arisen in response to the selective pressure of their use. This review uses the paradigm of the evolution and spread of beta‐lactamases and in particular beta‐lactamases active against antimicrobials used to treat Gram‐negative infections. The emergence and evolution particularly of CTX‐M extended‐spectrum beta‐lactamases (ESBLs) is described together with the molecular mechanisms responsible for both primary mutation and horizontal gene transfer. Reference is also made to other significant antibiotic resistance genes, resistance mechanisms in Gram‐negative bacteria, such as carbepenamases, and plasmid‐mediated fluoroquinolone resistance. The pathogen Staphylococcus aureus is reviewed in detail as an example of a highly successful Gram‐positive bacterial pathogen that has acquired and developed resistance to a wide range of antimicrobials. The role of selective pressures in the environment as well as the medical use of antimicrobials together with the interplay of various genetic mechanisms for horizontal gene transfer are considered in the concluding part of this review.
British Journal of Pharmacology (2008) 153, S406–S413; doi:10.1038/sj.bjp.0707632</description><subject>Animals</subject><subject>antibiotic resistance</subject><subject>Bacteria - genetics</subject><subject>Bacterial Infections - drug therapy</subject><subject>Bacterial Infections - genetics</subject><subject>Bacterial Infections - microbiology</subject><subject>beta‐lactamases</subject><subject>Drug Resistance, Microbial - genetics</subject><subject>ESBL</subject><subject>Genes, Bacterial - physiology</subject><subject>Humans</subject><subject>Molecular Epidemiology</subject><subject>MRSA</subject><subject>plasmids</subject><subject>Review</subject><subject>Staphylococcus aureus</subject><issn>0007-1188</issn><issn>1476-5381</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkb1vFDEQxS0EIkegpUQrCro9PP7eBgkiSCIdSgqoLa_Xe3jlsw97N-j-exzdiY80KazxaH7z9OyH0GvAa8BUvS_Tup_2ayyxFJQ8QStgUrScKniKVhhj2QIodYZelDJhXIeSP0dnoCgAcLFCm68pOLsEkxu394Pb-RTS9tCksbHBR29NCIem-G30Y23i3NTje59mb5vsii-zidY1WxddeYmejSYU9-pUz9H3L5-_XVy1m5vL64uPm9ZyzkUrOwDiBAdBuBiHjlEzOAu2t93AjGJjB45W79T2DBuLGe0NNsB7rMjQcUrP0Yej7n7pd26wLs7ZBL3PfmfyQSfj9f-T6H_obbrThAiFmagC704COf1cXJn1zhfrQjDRpaVoiSnrQMlHQVJtMsJVBd8-AKe05Fh_QROQBDNF7qH1EbI5lZLd-McyYH0fpy6TrnHqU5x14c2_D_2Ln_KrADkCv3xwh0fk9KfbK1UvvwEV-a0R</recordid><startdate>200803</startdate><enddate>200803</enddate><creator>Hawkey, P M</creator><general>Blackwell Publishing Ltd</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7QL</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200803</creationdate><title>Molecular epidemiology of clinically significant antibiotic resistance genes</title><author>Hawkey, P M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5556-79112e6516256fd943adec1cbc9d4a84f91e30003cb40ac043ba0a15b082d9533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>antibiotic resistance</topic><topic>Bacteria - genetics</topic><topic>Bacterial Infections - drug therapy</topic><topic>Bacterial Infections - genetics</topic><topic>Bacterial Infections - microbiology</topic><topic>beta‐lactamases</topic><topic>Drug Resistance, Microbial - genetics</topic><topic>ESBL</topic><topic>Genes, Bacterial - physiology</topic><topic>Humans</topic><topic>Molecular Epidemiology</topic><topic>MRSA</topic><topic>plasmids</topic><topic>Review</topic><topic>Staphylococcus aureus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hawkey, P M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hawkey, P M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular epidemiology of clinically significant antibiotic resistance genes</atitle><jtitle>British journal of pharmacology</jtitle><addtitle>Br J Pharmacol</addtitle><date>2008-03</date><risdate>2008</risdate><volume>153</volume><issue>S1</issue><spage>S406</spage><epage>S413</epage><pages>S406-S413</pages><issn>0007-1188</issn><eissn>1476-5381</eissn><abstract>Antimicrobials were first introduced into medical practice a little over 60 years ago and since that time resistant strains of bacteria have arisen in response to the selective pressure of their use. This review uses the paradigm of the evolution and spread of beta‐lactamases and in particular beta‐lactamases active against antimicrobials used to treat Gram‐negative infections. The emergence and evolution particularly of CTX‐M extended‐spectrum beta‐lactamases (ESBLs) is described together with the molecular mechanisms responsible for both primary mutation and horizontal gene transfer. Reference is also made to other significant antibiotic resistance genes, resistance mechanisms in Gram‐negative bacteria, such as carbepenamases, and plasmid‐mediated fluoroquinolone resistance. The pathogen Staphylococcus aureus is reviewed in detail as an example of a highly successful Gram‐positive bacterial pathogen that has acquired and developed resistance to a wide range of antimicrobials. The role of selective pressures in the environment as well as the medical use of antimicrobials together with the interplay of various genetic mechanisms for horizontal gene transfer are considered in the concluding part of this review.
British Journal of Pharmacology (2008) 153, S406–S413; doi:10.1038/sj.bjp.0707632</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>18311156</pmid><doi>10.1038/sj.bjp.0707632</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals antibiotic resistance Bacteria - genetics Bacterial Infections - drug therapy Bacterial Infections - genetics Bacterial Infections - microbiology beta‐lactamases Drug Resistance, Microbial - genetics ESBL Genes, Bacterial - physiology Humans Molecular Epidemiology MRSA plasmids Review Staphylococcus aureus |
| title | Molecular epidemiology of clinically significant antibiotic resistance genes |
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