Chemical Inhibition of the Mitochondrial Division Dynamin Reveals Its Role in Bax/Bak-Dependent Mitochondrial Outer Membrane Permeabilization

Mitochondrial fusion and division play important roles in the regulation of apoptosis. Mitochondrial fusion proteins attenuate apoptosis by inhibiting release of cytochrome c from mitochondria, in part by controlling cristae structures. Mitochondrial division promotes apoptosis by an unknown mechani...

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Veröffentlicht in:	Developmental cell 2008-02, Vol.14 (2), p.193-204
Hauptverfasser:	Cassidy-Stone, Ann, Chipuk, Jerry E., Ingerman, Elena, Song, Cheng, Yoo, Choong, Kuwana, Tomomi, Kurth, Mark J., Shaw, Jared T., Hinshaw, Jenny E., Green, Douglas R., Nunnari, Jodi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects bcl-2 Homologous Antagonist-Killer Protein - metabolism bcl-2-Associated X Protein - metabolism Biological and medical sciences Cell differentiation, maturation, development, hematopoiesis Cell physiology CELLBIO CELLCYCLE Cercopithecus aethiops CHEMBIO COS Cells Dynamins - antagonists & inhibitors Dynamins - ultrastructure Flow Cytometry Fundamental and applied biological sciences. Psychology HeLa Cells Humans Mitochondria - drug effects Mitochondria - metabolism Mitochondrial Membranes - drug effects Mitochondrial Membranes - metabolism Molecular and cellular biology Permeability - drug effects Quinazolinones - chemistry Quinazolinones - pharmacology Saccharomyces cerevisiae - cytology Saccharomyces cerevisiae - drug effects Structure-Activity Relationship
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