A detailed examination of cytokine abnormalities in Major Depressive Disorder

A detailed examination of cytokine abnormalities in Major Depressive Disorder

Abstract Recent technological advances offer an opportunity to further elucidate the complex cytokine network in Major Depressive Disorder (MDD). Twenty cytokines were simultaneously assessed in 49 individuals with MDD and 49 age and gender matched controls. Multiple pro-inflammatory and two anti-in...

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Veröffentlicht in:European neuropsychopharmacology 2008-03, Vol.18 (3), p.230-233
Hauptverfasser: Simon, N.M, McNamara, K, Chow, C.W, Maser, R.S, Papakostas, G.I, Pollack, M.H, Nierenberg, A.A, Fava, M, Wong, K.K
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Cardiovascular
Chemokines - metabolism
Cytokines
Cytokines - metabolism
Depression
Depressive Disorder, Major - metabolism
Female
Humans
Inflammation
Internal Medicine
Major Depressive Disorder
Male
Middle Aged
Psychiatric Status Rating Scales
Psychiatry
Reference Values
Sex Characteristics
Stress
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Zusammenfassung:Abstract Recent technological advances offer an opportunity to further elucidate the complex cytokine network in Major Depressive Disorder (MDD). Twenty cytokines were simultaneously assessed in 49 individuals with MDD and 49 age and gender matched controls. Multiple pro-inflammatory and two anti-inflammatory cytokines were significantly elevated in the MDD sample, including an antidepressant naïve subset. These data support a generalized chronic inflammatory state in MDD, and implicate additional cytokines and chemokines previously linked to cardiovascular disease.
ISSN:0924-977X
1873-7862
DOI:10.1016/j.euroneuro.2007.06.004