A CaVβ SH3/Guanylate Kinase Domain Interaction Regulates Multiple Properties of Voltage-gated Ca2+ Channels

Auxiliary Ca2+ channel β subunits (CaVβ) regulate cellular Ca2+ signaling by trafficking pore-forming α1 subunits to the membrane and normalizing channel gating. These effects are mediated through a characteristic src homology 3/guanylate kinase (SH3–GK) structural module, a design feature shared in...

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Veröffentlicht in:	The Journal of general physiology 2005-10, Vol.126 (4), p.365-377
Hauptverfasser:	Takahashi, Shoji X., Miriyala, Jayalakshmi, Tay, Lai Hock, Yue, David T., Colecraft, Henry M.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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