IKK/NF-κB regulates skeletal myogenesis via a signaling switch to inhibit differentiation and promote mitochondrial biogenesis

Nuclear factor κB (NF-κB) is involved in multiple skeletal muscle disorders, but how it functions in differentiation remains elusive given that both anti- and promyogenic activities have been described. In this study, we resolve this by showing that myogenesis is controlled by opposing NF-κB signali...

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Veröffentlicht in:	The Journal of cell biology 2008-02, Vol.180 (4), p.787-802
Hauptverfasser:	Bakkar, Nadine, Wang, Jingxin, Ladner, Katherine J, Wang, Huating, Dahlman, Jason M, Carathers, Micheal, Acharyya, Swarnali, Rudnicki, Michael A, Hollenbach, Andrew D, Guttridge, Denis C
Format:	Artikel
Sprache:	eng
Schlagworte:	Cellular differentiation Gene expression regulation Mice Muscle development Muscle fibers Muscles Myoblasts Plasmids Skeletal muscle Stem cells
Online-Zugang:	Volltext
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