Humanized anti‐CD4 monoclonal antibody therapy of autoimmune and inflammatory disease

Summary We have investigated the biological and therapeutic properties of a humanized anti‐CD4 MoAb, hlgGl‐CD4, in patients with refractory psoriasis and rheumatoid arthritis (RA). hIgGl‐CD4 is a modulating, non‐depleting MoAb, which induced a first‐dose reaction in most patients treated. It provide...

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Veröffentlicht in:	Clinical and experimental immunology 1997-11, Vol.110 (2), p.158-166
Hauptverfasser:	ISAACS, J. D., BURROWS, N., WING, M., KEOGAN, M. T., REBELLO, P. R. U. B., WATTS, R. A., PYE, R. J., NORRIS, P., HAZELMAN, B. L., HALE, G., WALDMANN, H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Animals Antibodies, Bispecific - immunology Antibodies, Bispecific - therapeutic use Antibodies, Monoclonal - immunology Antibodies, Monoclonal - therapeutic use anti‐CD4 Arthritis, Rheumatoid - drug therapy Arthritis, Rheumatoid - immunology Autoimmune Diseases - drug therapy Autoimmune Diseases - immunology Biological and medical sciences CAMPATH CD4 Antigens - immunology Female Humans Immunomodulators Immunotherapy Male Medical sciences Middle Aged Original Pharmacology. Drug treatments psoriasis Psoriasis - drug therapy Psoriasis - immunology Rats rheumatoid arthritis
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