Highly efficient and large-scale generation of functional dopamine neurons from human embryonic stem cells

We developed a method for the efficient generation of functional dopaminergic (DA) neurons from human embryonic stem cells (hESCs) on a large scale. The most unique feature of this method is the generation of homogeneous spherical neural masses (SNMs) from the hESC-derived neural precursors. These S...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2008-03, Vol.105 (9), p.3392-3397
Hauptverfasser:	Cho, Myung Soo, Lee, Young-Eun, Kim, Ji Young, Chung, Seungsoo, Cho, Yoon Hee, Kim, Dae-Sung, Kang, Sang-Moon, Lee, Haksup, Kim, Myung-Hwa, Kim, Jeong-Hoon, Leem, Joong Woo, Oh, Sun Kyung, Choi, Young Min, Hwang, Dong-Youn, Chang, Jin Woo, Kim, Dong-Wook
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Antibodies Biological Sciences Cell Culture Techniques - methods Cell Differentiation Cell lines Cell Transplantation Disease Models, Animal Dopamine Embryonic stem cells Embryonic Stem Cells - cytology Feeder cells Humans Methods Neurons Neurons - cytology Neurons - transplantation Neurotransmitters Parkinson Disease - therapy Rats Rodents Rotation Stem cells Studies Tissue grafting Transplantation Tumors
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